| Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis. | |
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MedLine Citation:
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PMID: 9152309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Venous thrombosis and inflammation are interrelated. P-selectin contributes to activation of leukocyte-mediated inflammation. Therefore, we hypothesized that the neutralization of P-selectin would decrease vein wall inflammation and thrombosis. METHODS: Twelve baboons underwent infrarenal inferior vena caval balloon occlusion to induce thrombosis. Two groups of four baboons received neutralizing intravenous anti-P-selectin antibody (PSab) GA6 or CY1748 before occlusion and at days 2 and 4. Four baboons received saline control injections. One baboon per group was killed at days 2, 6, and 13, and at 2 months. Analysis included phlebography, ultrasound, gadolinium (Gd)-enhanced magnetic resonance venography (reflecting vein wall inflammation), and histologic, morphometric, and protein evaluation of the vein wall. Thrombus presence or absence was assessed. RESULTS: By day 2 in PSab baboons, vein wall Gd enhancement was decreased in the mid-inferior vena cava and the right iliac vein (p < 0.05; GA6 vs control baboons), normalizing by 2 months. The mid-inferior vena cava revealed fewer neutrophils and total leukocytes in PSab baboons; however, for GA6 in the right iliac vein these decreases were not present despite the absence of Gd enhancement; they were decreased with CY1748. PSab baboons demonstrated significantly less thrombus than control baboons (p < 0.01, GA6 and CY1748 vs control baboons). CONCLUSIONS: Anti-P-selectin antibody decreases vein wall inflammation and thrombus formation. Inhibition of P-selectin may be useful in venous thrombosis prophylaxis. |
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Authors:
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L J Downing; T W Wakefield; R M Strieter; M R Prince; F J Londy; J B Fowlkes; M S Hulin; A M Kadell; C A Wilke; S L Brown; S K Wrobleski; M D Burdick; D C Anderson; L J Greenfield |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter Volume: 25 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-06-06 Completed Date: 1997-06-06 Revised Date: 2011-07-29 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 816-27; discussion 828 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109-0329, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Antibodies / blood Antibodies, Monoclonal / therapeutic use* Chronic Disease Contrast Media Disease Models, Animal Drug Evaluation, Preclinical Gadolinium / diagnostic use Iliac Vein* / pathology, radiography, ultrasonography Magnetic Resonance Angiography P-Selectin / immunology* Papio Thrombosis / diagnosis, drug therapy*, immunology, pathology Time Factors Vasculitis / diagnosis, drug therapy*, immunology, pathology Vena Cava, Inferior* / pathology, radiography, ultrasonography |
| Grant Support | |
ID/Acronym/Agency:
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HL50057/HL/NHLBI NIH HHS; HL53355/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antibodies, Monoclonal; 0/CY1748 monoclonal antibody; 0/Contrast Media; 0/GA6 monoclonal antibody; 0/P-Selectin; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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