Document Detail


Anti-oxidative activity of an aqueous suspension of commercial preparation of the mushroom Coprinus comatus.
MedLine Citation:
PMID:  20657376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study the effects of an aqueous suspension of a commercial preparation of the mushroom Coprinus comatus on oxidative stress induced in rats by alloxane and carbon tetrachloride was examined. The effects were estimated from changes in the biochemical parameters (xanthine oxidase, glutathione peroxidase and catalase activity, reduced glutathione content, and extent of lipid peroxidation) of liver homogenate as well as histological changes in the liver of the rats treated with alloxane and carbon tetrachloride. Two screening doses of alloxane sufficient to induce diabetes in rats did not have any significant effect on the examined biochemical parameters of liver homogenate or on the cytoarchitectonics of liver cross-sections. Treatment with carbon tetrachloride resulted in a significant increase in the intensity of lipid peroxidation and peroxydasis activity, as well as with decrease in catalase activity. Certain changes in liver cross sections were detected, such is lymphocyte infiltration of dilated sinusoid capillaries. Administration of Coprinus comatus suspension thus showed antioxidative potential, evidenced by an increase of antioxidative status of liver homogenate and prevention of histological changes in liver cross sections.
Authors:
Mira Popović; Sasa Vukmirović; Nebojsa Stilinović; Ivan Capo; Vida Jakovljević
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-24
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  15     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  4564-71     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Faculty of Sciences, Trg Dositeja Obradovica 3, 21000 Novi Sad, Serbia. mira.popovic@dh.uns.ac.rs
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MeSH Terms
Descriptor/Qualifier:
Agaricales / chemistry*
Alloxan
Animals
Antioxidants / isolation & purification,  pharmacology*
Carbon Tetrachloride
Lipid Peroxidation / drug effects
Liver / metabolism
Oxidation-Reduction / drug effects
Oxidative Stress / drug effects*
Rats
Suspensions
Treatment Outcome
Water
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Suspensions; 50-71-5/Alloxan; 56-23-5/Carbon Tetrachloride; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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