| Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet. | |
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MedLine Citation:
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PMID: 20627120 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet. |
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Authors:
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Rui Liu; JingZhao Zhang; WenCong Liu; Yoshiyuki Kimura; YiNan Zheng |
Publication Detail:
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Type: Journal Article Date: 2010-08-19 |
Journal Detail:
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Title: Fitoterapia Volume: 81 ISSN: 1873-6971 ISO Abbreviation: Fitoterapia Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1079-87 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun-shi, Jilin 130118, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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