| Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang () in female rats with diet-induced obesity. | |
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MedLine Citation:
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PMID: 22139544 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effects of Chang-Chul-Eui-Ee-In-Tang (, CCEET), modififi ed CCEET (MCCEET), and Semen Coicis (SC, a major component of CCEET) on energy and glucose homeostasis. The possible mechanism of action of CCEET was also determined. METHODS: A total of 100 Sprague Dawley female rats were randomly assigned to 5 groups, with 20 in each group. Rats in 4 groups were fed with a high fat diet supplementation (2 g/kg body weight), and water extracts of CCEET, MCCEET, SC, and cellulose (negative control), respectively. The last group was fed with a low-fat diet as a positive control. Results: CCEET and MCCEET decreased body weight and body fat (mesenteric and retroperitoneal fat) more than SC. This decrease was due to decreased energy intake and increased energy expenditure and fat oxidation. The improvement in energy homeostasis was associated with the enhancement of the hypothalamic leptin signalling pathway involving potentiating the phosphorylation of the signal transducer and activator of transcription-3, as well as attenuating the phosphorylation of 5' adenosine monophosphate-activated protein kinase (AMPK). Both CCEET and MCCEET improved glucose tolerance without changing serum insulin levels during an oral glucose tolerance test but MCCEET had a better effect than CCEET. CONCLUSIONS: Both CCEET and MCCEET safely exerted anti-obesity effects by enhancing energy balance in female rats with diet-induced obesity; MCCEET showed a better effect on glucose homeostasis. |
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Authors:
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Sunmin Park; Jung Bok Lee; James W Daily |
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Publication Detail:
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Type: Journal Article Date: 2011-12-03 |
Journal Detail:
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Title: Chinese journal of integrative medicine Volume: 17 ISSN: 1672-0415 ISO Abbreviation: Chin J Integr Med Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181180 Medline TA: Chin J Integr Med Country: China |
Other Details:
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Languages: eng Pagination: 925-32 Citation Subset: IM |
Affiliation:
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Department of Food and Nutrition, Obesity/Diabetes Research Institutes, Hoseo University, Asan, 336-795, South Korea, smpark@hoseo.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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