| Anti-NMDA-Receptor Encephalitis: Case Report and Literature Review of an Under-Recognized Condition. | |
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MedLine Citation:
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PMID: 21318640 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Anti-N-methyl-D-aspartate receptor (anti-NMDA-R) encephalitis is an immune-mediated syndrome that remains under-recognized despite a growing body of literature. This syndrome has been predominantly described in young females with a constellation of symptoms, including personality changes, autonomic dysfunction and neurologic decompensation. It is commonly associated with mature ovarian teratomas. We describe the classic presentation of anti-NMDA-R encephalitis in three dramatically different patients: Case A, a young woman with ovarian teratoma; Case B, the eldest case reported to date; and Case C, a young male with no identifiable tumor. We review the literature summarizing the differential diagnosis, investigative approach, treatment options and challenges inherent to this disorder. We advocate good supportive care, involvement of multiple health disciplines and use of immune-modulating therapies in patient management. These cases underscore the need for increased awareness and high diagnostic suspicion when approaching the patient with suspected viral encephalitis. |
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Authors:
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Gregory S Day; Sasha M High; Bianca Cot; David F Tang-Wai |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-12 |
Journal Detail:
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Title: Journal of general internal medicine Volume: - ISSN: 1525-1497 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605834 Medline TA: J Gen Intern Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada, gregg.day@utoronto.ca. |
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