Document Detail


Anti-N-methyl-D-aspartate receptor encephalitis during pregnancy.
MedLine Citation:
PMID:  20625099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To report 3 patients who developed anti-N-methyl-d-aspartate receptor encephalitis during pregnancy. DESIGN: Case reports. SETTING: University hospitals. Patients Three young women developed at 14, 8, and 17 weeks of gestation acute change of behavior, prominent psychiatric symptoms, progressive decrease of consciousness, seizures, dyskinesias, and autonomic dysfunction. MAIN OUTCOME MEASURES: Clinical, radiological, and immunological findings. RESULTS: The 3 patients had cerebrospinal fluid pleocytosis, normal magnetic resonance imaging, and electroencephalogram showing slow activity. All had higher antibody titers in cerebrospinal fluid than in serum and 2 had ovarian teratomas that were removed. The pregnancy was terminated in 1 patient with recurrent bilateral teratomas. All patients had substantial neurological recoveries, and the 2 newborns were normal. Results of extensive antibody testing in 1 of the babies were negative. CONCLUSION: The current study shows that anti-NMDAR encephalitis during pregnancy can have a good outcome for the mother and newborn.
Authors:
Monisha A Kumar; Ankit Jain; Valerie E Dechant; Tsukasa Saito; Timothy Rafael; Hitoshi Aizawa; Kevin C Dysart; Takayuki Katayama; Yasuo Ito; Nobuo Araki; Tatsuya Abe; Rita Balice-Gordon; Josep Dalmau
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of neurology     Volume:  67     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-13     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  884-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, University of Pennsylvania, Philadelphia, 19104, USA.
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MeSH Terms
Descriptor/Qualifier:
Antibodies / blood*
Encephalitis / immunology*,  physiopathology
Female
Humans
Pregnancy
Receptors, N-Methyl-D-Aspartate / immunology*
Young Adult
Grant Support
ID/Acronym/Agency:
1RC1NS068204-01/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies; 0/Receptors, N-Methyl-D-Aspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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