| Anti-Myocardial Fibrosis Effect of a Polysaccharide from the Fruits of Schisandra Chinensis. | |
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MedLine Citation:
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PMID: 23270835 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A water-soluble polysaccharide, named as SCPW, was extracted and fractioned from the fruits of Schisandra chinensis by DEAE-cellulose anion exchange and a Sepharose CL-6B column chromatography. The monosaccharide composition of SCPW determined by gas chromatography (GC) was identified that it was composed of arabinose, xylose, glucose and galactose with a relative molar ratio of 15:18:32:35, and contained 96.5% of total carbohydrate, 39.8% of uronic acid and no protein was detected in it. In vitro experiment showed that SCPW significantly inhibited the hyperplasia of Angiotensin II (AngII)-induced cardiac fibroblast (CFb) of cultured neonatal rats. In vivo experiment verified that SCPW could remarkably reduce the myocardial weight and left ventricular weight. Furthermore, SCPW also decreased the contents of Hyp, MDA, LDH and CK, and increased the activity of SOD in serum of Iso-induced rats. The overall findings indicate that SCPW could be used as a novel promising agent for the treatment of myocardial fibrosis. |
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Authors:
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Tiechao Jiang; Beibei Du; Ping Yang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-24 |
Journal Detail:
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Title: International journal of biological macromolecules Volume: - ISSN: 1879-0003 ISO Abbreviation: Int. J. Biol. Macromol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909578 Medline TA: Int J Biol Macromol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Cardiac Department of China-Japan United Hospital, JiLin University, JiLin, 130031, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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