Document Detail


Anti-Myocardial Fibrosis Effect of a Polysaccharide from the Fruits of Schisandra Chinensis.
MedLine Citation:
PMID:  23270835     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A water-soluble polysaccharide, named as SCPW, was extracted and fractioned from the fruits of Schisandra chinensis by DEAE-cellulose anion exchange and a Sepharose CL-6B column chromatography. The monosaccharide composition of SCPW determined by gas chromatography (GC) was identified that it was composed of arabinose, xylose, glucose and galactose with a relative molar ratio of 15:18:32:35, and contained 96.5% of total carbohydrate, 39.8% of uronic acid and no protein was detected in it. In vitro experiment showed that SCPW significantly inhibited the hyperplasia of Angiotensin II (AngII)-induced cardiac fibroblast (CFb) of cultured neonatal rats. In vivo experiment verified that SCPW could remarkably reduce the myocardial weight and left ventricular weight. Furthermore, SCPW also decreased the contents of Hyp, MDA, LDH and CK, and increased the activity of SOD in serum of Iso-induced rats. The overall findings indicate that SCPW could be used as a novel promising agent for the treatment of myocardial fibrosis.
Authors:
Tiechao Jiang; Beibei Du; Ping Yang
Related Documents :
8369465 - Myocardial dysfunction following cardiopulmonary bypass: recovery patterns, predictors ...
8944995 - Importance of metabolic function of the natural lung evaluated by prolonged exclusion o...
25128175 - Mitochondrial depolarization and electrophysiological changes during ischemia in the ra...
24487335 - Multiple cerebral infarction associated with neuroleptic-induced lupus anticoagulant.
8781825 - Captopril adjuvant therapy to beta-blockers and nitrates improves post-myocardial infar...
22685115 - Myocardial cxcr4 expression is required for mesenchymal stem cell mediated repair follo...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-24
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  -     ISSN:  1879-0003     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Cardiac Department of China-Japan United Hospital, JiLin University, JiLin, 130031, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physical modifications of polysaccharide from Inonotus obliquus and the antioxidant properties.
Next Document:  Exploiting the synergistic effect of chitosan-EDTA conjugate with MSA for the early recovery from co...