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Anti-Myocardial Fibrosis Effect of a Polysaccharide from the Fruits of Schisandra Chinensis.
MedLine Citation:
PMID:  23270835     Owner:  NLM     Status:  Publisher    
A water-soluble polysaccharide, named as SCPW, was extracted and fractioned from the fruits of Schisandra chinensis by DEAE-cellulose anion exchange and a Sepharose CL-6B column chromatography. The monosaccharide composition of SCPW determined by gas chromatography (GC) was identified that it was composed of arabinose, xylose, glucose and galactose with a relative molar ratio of 15:18:32:35, and contained 96.5% of total carbohydrate, 39.8% of uronic acid and no protein was detected in it. In vitro experiment showed that SCPW significantly inhibited the hyperplasia of Angiotensin II (AngII)-induced cardiac fibroblast (CFb) of cultured neonatal rats. In vivo experiment verified that SCPW could remarkably reduce the myocardial weight and left ventricular weight. Furthermore, SCPW also decreased the contents of Hyp, MDA, LDH and CK, and increased the activity of SOD in serum of Iso-induced rats. The overall findings indicate that SCPW could be used as a novel promising agent for the treatment of myocardial fibrosis.
Tiechao Jiang; Beibei Du; Ping Yang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-24
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  -     ISSN:  1879-0003     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Cardiac Department of China-Japan United Hospital, JiLin University, JiLin, 130031, China.
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