Document Detail


Anti-Myelin Oligodendrocyte Glycoprotein Antibodies in Pediatric Patients With Optic Neuritis.
MedLine Citation:
PMID:  22371853     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG) in pediatric patients with isolated and recurrent optic neuritis (ON). DESIGN: Observational prospective case series. SETTING: Six pediatric hospitals in Germany and Austria. Patients  Thirty-seven patients 18 years or younger with single or recurrent episodes of ON were recruited from 6 different hospitals. MAIN OUTCOME MEASURES: Clinical features, magnetic resonance imaging findings, intrathecal IgG synthesis, and outcome were recorded. A live cell-based immunofluorescence assay was used to measure serum IgG antibodies to MOG and aquaporin 4. RESULTS: A single episode of ON was observed in 10 patients, and 15 experienced 2 to 12 episodes. The acute episode of ON was part of a clinically isolated syndrome in 12 patients, of whom 8 were subsequently classified as having multiple sclerosis. High-titer serum MOG-IgG antibodies (≥1:160) were detected in 17 patients (46%). In addition, high titers of MOG-IgG antibodies were more frequently observed in 12 of the 15 patients with recurrent episodes of ON (80%; median titer, 1:640) compared with 2 of the 10 patients with monophasic ON (20%; median titer, 0) and 3 of the 12 patients with ON as part of a clinically isolated syndrome (25%; median titer, 0). CONCLUSION: High-titer MOG-IgG antibodies are predominantly detected in pediatric patients with recurrent ON, indicating that anti-MOG-specific antibodies may exert a direct role in the pathogenesis of ON in this subgroup.
Authors:
Kevin Rostasy; Simone Mader; Kathrin Schanda; Peter Huppke; Jutta Gärtner; Verena Kraus; Michael Karenfort; Daniel Tibussek; Astrid Blaschek; Barbara Bajer-Kornek; Steffen Leitz; Mareike Schimmel; Franziska Di Pauli; Thomas Berger; Markus Reindl
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-27
Journal Detail:
Title:  Archives of neurology     Volume:  -     ISSN:  1538-3687     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics IV (Dr Rostasy), and Clinical Department of Neurology (Mss Mader and Schanda and Drs Di Pauli, Berger, and Reindl), Innsbruck Medical University, Innsbruck, Austria; Department of Pediatrics and Pediatric Neurology, Georg-August University Göttingen, Göttingen, Germany (Drs Huppke and Gärtner); Children's Hospital Technische Universität (Dr Kraus), Department of Pediatric Neurology and Developmental Medicine, Dr von Hauner's Children's Hospital, University of Munich (Dr Blaschek), and Pediatric Neurology, Department of Pediatrics, Klinikum Dritter Orden (Dr Leitz), Munich, Germany; Division of Pediatric Neurology, Department of General Pediatrics, Heinrich Heine University Düsseldorf, Düsseldorf, Germany (Dr Karenfort); Department of Neuropediatrics, Children's Hospital, Klinikum Leverkusen, Leverkusen, Germany (Dr Tibussek); Department of Neurology, Medical University of Vienna, Vienna, Austria (Dr Bajer-Kornek); and Children's Hospital Städtische Kliniken Augsburg, Augsburg, Germany (Dr Schimmel).
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