| Anti-Jo-1 antisynthetase syndrome. | |
MedLine Citation:
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PMID: 21125186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Given a lack of population-based studies, we report an epidemiological-clinic study of anti-Jo-1 antisynthetase syndrome (ASS). PATIENTS AND METHODS: To study a retrospective cohort of a single-center from 1980 to 2010. Clinical-laboratory and demographic data were obtained from medical files. All patients fulfilled the Bohan and Peter criteria (1975) and presented anti-Jo-1, articular, muscle and lung involvement. Eighteen patients with anti-Jo-1 ASS were analyzed. RESULTS: The mean age at disease onset was 39.9 ± 15.7 years and average disease duration was 9.7 ± 7.0 years. All subjects were white, and 94.4% were female. Constitutional symptoms occurred in 50 % of cases. There was cutaneous and gastrointestinal tract involvement in 66.6% and 55.6% of cases, respectively. No cases manifested neurologic or cardiac involvement. Half of the patients showed incipient pneumopathy, ground-glass opacities and basal pulmonary fibrosis. There was one case of tuberculosis, three of herpes zoster and one of non-Hodgkin lymphoma. One death occurred due to sepsis shock (hospital bronchopneumonia). All patients received prednisone (1mg/kg/day) and 12 (66.7%) participants received methyl prednisolone pulse therapy (1g/day, 3 days). Various immunosuppressants were used as corticosteroid tapers, depending on tolerance, side effects and/or refractoriness. Although disease relapse (clinical and/or laboratory) occurred in 87.5% of cases, 12 out of 16 patients (75%) were in disease remission at study endpoint. CONCLUSION: In the present study, almost all patients were white females and the disease relapse rate was high. |
Authors:
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Samuel Katsuyuki Shinjo; Mauricio Levy-Neto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revista brasileira de reumatologia Volume: 50 ISSN: 1809-4570 ISO Abbreviation: Rev Bras Reumatol Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-12-02 Completed Date: 2011-06-16 Revised Date: 2012-05-08 |
Medline Journal Info:
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Nlm Unique ID: 0404256 Medline TA: Rev Bras Reumatol Country: Brazil |
Other Details:
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Languages: eng; por Pagination: 492-500 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. samuel.shinjo@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cohort Studies Female Histidine-tRNA Ligase / immunology* Humans Male Middle Aged Myositis / immunology Retrospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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EC 6.1.1.21/Histidine-tRNA Ligase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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