Document Detail


Anti-Jo-1 antisynthetase syndrome.
MedLine Citation:
PMID:  21125186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Given a lack of population-based studies, we report an epidemiological-clinic study of anti-Jo-1 antisynthetase syndrome (ASS).
PATIENTS AND METHODS: To study a retrospective cohort of a single-center from 1980 to 2010. Clinical-laboratory and demographic data were obtained from medical files. All patients fulfilled the Bohan and Peter criteria (1975) and presented anti-Jo-1, articular, muscle and lung involvement. Eighteen patients with anti-Jo-1 ASS were analyzed.
RESULTS: The mean age at disease onset was 39.9 ± 15.7 years and average disease duration was 9.7 ± 7.0 years. All subjects were white, and 94.4% were female. Constitutional symptoms occurred in 50 % of cases. There was cutaneous and gastrointestinal tract involvement in 66.6% and 55.6% of cases, respectively. No cases manifested neurologic or cardiac involvement. Half of the patients showed incipient pneumopathy, ground-glass opacities and basal pulmonary fibrosis. There was one case of tuberculosis, three of herpes zoster and one of non-Hodgkin lymphoma. One death occurred due to sepsis shock (hospital bronchopneumonia). All patients received prednisone (1mg/kg/day) and 12 (66.7%) participants received methyl prednisolone pulse therapy (1g/day, 3 days). Various immunosuppressants were used as corticosteroid tapers, depending on tolerance, side effects and/or refractoriness. Although disease relapse (clinical and/or laboratory) occurred in 87.5% of cases, 12 out of 16 patients (75%) were in disease remission at study endpoint.
CONCLUSION: In the present study, almost all patients were white females and the disease relapse rate was high.
Authors:
Samuel Katsuyuki Shinjo; Mauricio Levy-Neto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista brasileira de reumatologia     Volume:  50     ISSN:  1809-4570     ISO Abbreviation:  Rev Bras Reumatol     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-06-16     Revised Date:  2012-05-08    
Medline Journal Info:
Nlm Unique ID:  0404256     Medline TA:  Rev Bras Reumatol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  492-500     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. samuel.shinjo@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cohort Studies
Female
Histidine-tRNA Ligase / immunology*
Humans
Male
Middle Aged
Myositis / immunology
Retrospective Studies
Young Adult
Chemical
Reg. No./Substance:
EC 6.1.1.21/Histidine-tRNA Ligase

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