| Anti-inflammatory function of Nodosin via inhibition of IL-2. | |
| | |
MedLine Citation:
|
PMID: 20128050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial. |
| | |
Authors:
|
Jiyu Li; Junming Du; Lijuan Sun; Jianwen Liu; Zhiwei Quan |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of Chinese medicine Volume: 38 ISSN: 0192-415X ISO Abbreviation: Am. J. Chin. Med. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-02-03 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7901431 Medline TA: Am J Chin Med Country: Singapore |
Other Details:
|
Languages: eng Pagination: 127-42 Citation Subset: IM |
Affiliation:
|
Institute of Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University, China. leejiyu@sina.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Inflammatory Agents / isolation & purification, pharmacology, therapeutic use* Cell Cycle / drug effects DNA Replication / drug effects Diterpenes / isolation & purification, pharmacology, therapeutic use* Drugs, Chinese Herbal / chemistry, pharmacology, therapeutic use* Ear Edema / chemically induced, drug therapy, immunology Female Interleukin-2 / antagonists & inhibitors*, blood Isodon / chemistry* Male Mice Mice, Inbred BALB C Phytotherapy Plant Components, Aerial RNA, Messenger / metabolism Rabdosia / chemistry* T-Lymphocytes / drug effects*, metabolism Xylenes |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 0/Diterpenes; 0/Drugs, Chinese Herbal; 0/Interleukin-2; 0/RNA, Messenger; 0/Xylenes; 0/nodosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Icariin Inhibits the Increased Inward Calcium Currents Induced by Amyloid-beta(25-35) Peptide in CA1...
Next Document: Comparison of Puerariae Radix and Its Hydrolysate on Stimulation of Hyaluronic Acid Production in NH...