Document Detail

Anti-inflammatory function of Nodosin via inhibition of IL-2.
MedLine Citation:
PMID:  20128050     Owner:  NLM     Status:  MEDLINE    
In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin. In the current study, Nodosin suppressed the overproduction of the T lymphocytes; moreover, cell mitosis cycle was modulated by interfering with DNA replication in G1 stages via inhibition of IL-2 cytokine secretion at the mRNA level by Nodosin. Interestingly, Xylene-induced mouse tumescence model results suggested Nodosin depressed the murine ear-swelling extent and the level of IL-2 in the blood serum. Finally, Nodosin possessed significant anti-inflammatory effects and is a potential candidate for further clinical trial.
Jiyu Li; Junming Du; Lijuan Sun; Jianwen Liu; Zhiwei Quan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of Chinese medicine     Volume:  38     ISSN:  0192-415X     ISO Abbreviation:  Am. J. Chin. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901431     Medline TA:  Am J Chin Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  127-42     Citation Subset:  IM    
Institute of Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University, China.
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MeSH Terms
Anti-Inflammatory Agents / isolation & purification,  pharmacology,  therapeutic use*
Cell Cycle / drug effects
DNA Replication / drug effects
Diterpenes / isolation & purification,  pharmacology,  therapeutic use*
Drugs, Chinese Herbal / chemistry,  pharmacology,  therapeutic use*
Edema / chemically induced,  drug therapy,  immunology
Interleukin-2 / antagonists & inhibitors*,  blood
Isodon / chemistry*
Mice, Inbred BALB C
Plant Components, Aerial
RNA, Messenger / metabolism
Rabdosia / chemistry*
T-Lymphocytes / drug effects*,  metabolism
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Diterpenes; 0/Drugs, Chinese Herbal; 0/Interleukin-2; 0/RNA, Messenger; 0/Xylenes; 0/nodosin

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