Document Detail


Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug "Shin-i" (Flos Magnoliae).
MedLine Citation:
PMID:  17340515     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The anti-inflammatory effects of the major components of the dried flower buds of MAGNOLIA SALICIFOLIA were determined using the pouch granuloma method in mice. Though alkaloids, fatty acids, essential oils, and lignans had no anti-inflammatory effects, neolignans (magnoshinin and magnosalin) significantly inhibited the granuloma tissue formation. The inhibitory effect of magnoshinin was particularly strong, being nearly half of that of hydrocortisone acetate when administered orally. Some differences were noted in the mode of action between the neolignans and the steroidal drugs as the neolignans selectively inhibited the granuloma tissue formation but did not affect the exudation of pouch fluid. The structural specificity of neolignans was also found on their anti-inflammatory effect.
Authors:
M Kimura; J Suzuki; T Yamada; M Yoshizaki; T Kikuchi; S Kadota; S Matsuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  51     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  2007-03-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  291-3     Citation Subset:  -    
Affiliation:
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Japan.
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