Document Detail

The Anti-Inflammatory Actions of Exercise Training.
MedLine Citation:
PMID:  25431545     Owner:  NLM     Status:  Publisher    
The list of diseases with a known inflammatory etiology is growing. Cardiovascular disease, osteoporosis, diabetes, geriatric cachexia, and Alzheimer's disease have all been shown to be linked to or exacerbated by aberrantly regulated inflammatory processes. Nevertheless, there is mounting evidence that those who are physically active, or who become physically active, have a reduction in biomarkers associated with chronic inflammation. There was strong early consensus that exercise-induced reductions in inflammation were explained by body mass index or body fatness, but recent studies provide support for the contention that exercise has body fat-independent anti-inflammatory effects. With few exceptions, the anti-inflammatory effects of exercise appear to occur regardless of age or the presence of chronic diseases. What remains unclear are the mechanisms by which exercise training induces these anti-inflammatory effects, but there are several intriguing possibilities, including release of endogenous products, such as heat shock proteins; selective reduction of visceral adipose tissue mass or reducing infiltration of adipocytes by macrophages; shift in immune cell phenotype; cross-tolerizing effects; or exercise-induced shifts in accessory proteins of toll-like receptor signaling. However, future research endeavors are likely to uncover additional potential mechanisms, and it could be some time before functional mechanisms are made clear. In summary, the potential anti-inflammatory influences of exercise training may provide a low-cost, readily available, and effective treatment for low-grade systemic inflammation and could contribute significantly to the positive effects of exercise training on chronic disease.
Michael G Flynn; Brian K McFarlin; Melissa M Markofski
Related Documents :
3997925 - A study of quadriceps excursion, torque, and the effect of patellectomy on cadaver knees.
16643195 - Shoulder terminal range eccentric antagonist/concentric agonist strength ratios in over...
6660205 - Acupuncture and rehabilitation (iii) effects of acupuncture applied to the normal side ...
18272795 - The influence of arthroscopic subscapularis tendon and capsule release on internal rota...
17947505 - Lower body negative pressure exercise plus brief postexercise lower body negative press...
2318775 - 31p-nmr spectroscopy and the metabolic properties of different muscle fibers.
Publication Detail:
Journal Detail:
Title:  American journal of lifestyle medicine     Volume:  1     ISSN:  1559-8276     ISO Abbreviation:  Am J Lifestyle Med     Publication Date:  2007 5 
Date Detail:
Created Date:  2014-11-28     Completed Date:  -     Revised Date:  2014-11-29    
Medline Journal Info:
Nlm Unique ID:  101300023     Medline TA:  Am J Lifestyle Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  220-235     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  An Analysis Pipeline with Statistical and Visualization-Guided Knowledge Discovery for Michigan-Styl...
Next Document:  When Do Socioeconomic Resources Matter Most in Early Childhood?