Document Detail


Anti-Infectious Agents against MRSA.
MedLine Citation:
PMID:  23262449     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Clinically useful antibiotics, β-lactams and vancomycin, are known to inhibit bacterial cell wall peptidoglycan synthesis. Methicillin-resistant Staphylococcus aureus (MRSA) has a unique cell wall structure consisting of peptidoglycan and wall teichoic acid. In recent years, new anti-infectious agents (spirohexaline, tripropeptin C, DMPI, CDFI, cyslabdan, 1835F03, and BPH-652) targeting MRSA cell wall biosynthesis have been discovered using unique screening methods. These agents were found to inhibit important enzymes involved in cell wall biosynthesis such as undecaprenyl pyrophosphate (UPP) synthase, FemA, flippase, or UPP phosphatase. In this review, the discovery, the mechanism of action, and the future of these anti-infectious agents are described.
Authors:
Nobuhiro Koyama; Junji Inokoshi; Hiroshi Tomoda
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Publication Detail:
Type:  Journal Article     Date:  2012-12-24
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  18     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  204-24     Citation Subset:  IM    
Affiliation:
Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. tomodah@pharm.kitasato-u.ac.jp.
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