| Anti-IgA-mediated transfusion reactions in Canada. | |
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MedLine Citation:
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PMID: 6607096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During a 6-year period (1977 to 1982) blood samples from 152 Canadian patients were referred to the national reference laboratory of the Canadian Red Cross Society because the referring hospitals had not been able to determine the cause of the patients' severe nonhemolytic transfusion reactions. Twenty-one patients were found to be IgA deficient, and 12 of them had strong class-specific anti-IgA antibodies, which were presumed to have been responsible for the reactions. The spectrum of symptoms that accompanied these violent reactions was documented for 10 of the patients. As a probable minimum, the incidence of anti-IgA-mediated reactions averaged 1.3 per million units of blood or blood products transfused during this period. |
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Authors:
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C Laschinger; F A Shepherd; D H Naylor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian Medical Association journal Volume: 130 ISSN: 0008-4409 ISO Abbreviation: Can Med Assoc J Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-03-02 Completed Date: 1984-03-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0414110 Medline TA: Can Med Assoc J Country: CANADA |
Other Details:
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Languages: eng Pagination: 141-4 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Anti-Idiotypic
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immunology* Blood Transfusion / adverse effects* Canada HLA Antigens / immunology Humans IgA Deficiency Immunoglobulin A / analysis, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/HLA Antigens; 0/Immunoglobulin A |
| Comments/Corrections | |
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