| Anti-IL-1 molecules: new comers and new indications. | |
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MedLine Citation:
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PMID: 20045371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interleukin 1 family is composed by the interleukin 1 (IL-1) and its natural occurring inhibitor, the interleukin 1 receptor antagonist (IL-1Ra). The role of both molecules in rheumatoid arthritis has been widely established, and in this sense new molecules blocking IL-1 actions are under investigation. Anakinra is the recombinant form of IL-1Ra, and has proven to be well tolerated and indicated in the treatment of rheumatoid arthritis. Nevertheless, other molecules such as mAb anti-IL-1 and IL-1 Trap are being developed. Moreover, the recent relation of IL-1 in the inflammasome and pathways of innate immunity has lead to new indications of anti-IL-1 molecules, especially in the autoinflammatory syndromes as well as in other inflammatory diseases. Herein we have performed a review of the literature, limited to English language journals (PUBMED search: combination of descriptors IL-1 and anakinra, systemic juvenile idiopathic arthritis, adult's onset Still's disease, autoinflammatory syndromes, gout, pseudogout, ankylosing spondylitis, and systemic lupus erythematosus from January 1985-December 2008) emphasizing the possible new indications. Although sufficient data is not yet available to fully assess the efficacy and safety of anti-IL-1 molecules in patients with inflammatory disorders other than rheumatoid arthritis, new data is promising. |
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Authors:
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Anna Molt?; Alejandro Oliv? |
Publication Detail:
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Type: Journal Article; Review Date: 2009-12-31 |
Journal Detail:
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Title: Joint, bone, spine : revue du rhumatisme Volume: 77 ISSN: 1778-7254 ISO Abbreviation: Joint Bone Spine Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100938016 Medline TA: Joint Bone Spine Country: France |
Other Details:
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Languages: eng Pagination: 102-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Soci?t? fran?aise de rhumatologie. Published by Elsevier SAS. All rights reserved. |
Affiliation:
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Rheumatology Section, Hospital Universitari Germans Trias i Pujol, Ctra del Canyet s/n, 08916 Badalona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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therapeutic use* Humans Interleukin 1 Receptor Antagonist Protein / antagonists & inhibitors, immunology Interleukin-1alpha / antagonists & inhibitors, immunology* Interleukin-1beta / antagonists & inhibitors, immunology* Receptors, Interleukin-1 / antagonists & inhibitors, immunology Rheumatic Diseases / drug therapy*, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1alpha; 0/Interleukin-1beta; 0/Receptors, Interleukin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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