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Anti-Hyperglycemic Effect of Vaccinium arctostaphylos in Type 2 Diabetic Patients: A Randomized Controlled Trial.
MedLine Citation:
PMID:  23727759     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Type 2 diabetes mellitus is a common disease. Preliminary data indicate that Vaccinium arctostaphylos L. (Caucasian whortleberry) has a potential effect in glycemic control. Thus, the efficacy and safety of a standardized whortleberry fruit hydroalcoholic extract in the treatment of type 2 diabetic patients were studied. Methods: This randomized double-blind placebo-controlled clinical trial consisted of 37 patients aged 40-60 years with type 2 diabetes who were resistant to conventional oral anti-hyperglycemic drugs. The patients were treated with the whortleberry fruit hydroalcoholic extract (1 capsule = 350 mg, every 8 h for 2 months) in combination with anti-hyperglycemic drugs, and the effects on the blood levels of fasting glucose, 2-hour postprandial glucose, glycosylated hemoglobin (HbA1c), and liver/kidney function were tested, evaluated, and compared with a placebo group (n = 37). Results: The extract significantly lowered the blood levels of fasting glucose, 2-h postprandial glucose, and HbA1c (p = 0.007, p <0.001, and p = 0.005, respectively) without any significant effects on the liver/kidney function (p >0.05) compared with placebo at the end. No adverse effects were reported. Conclusion: Whortleberry may safely improve glycemic control in type 2 diabetic patients.
Authors:
Saeed Kianbakht; Behrooz Abasi; Fataneh Hashem Dabaghian
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Publication Detail:
Type:  Journal Article     Date:  2013-02-19
Journal Detail:
Title:  Forschende Komplementärmedizin (2006)     Volume:  20     ISSN:  1661-4127     ISO Abbreviation:  Forsch Komplementmed     Publication Date:  2013  
Date Detail:
Created Date:  2013-06-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101269884     Medline TA:  Forsch Komplementmed     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 S. Karger AG, Basel.
Affiliation:
Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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