| Anti-HIV-1 activity of poly(mandelic acid) derivatives. | |
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MedLine Citation:
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PMID: 17949101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water-soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were prepared via a step-growth mechanism, yielding linear polyesters. The polymers were characterized by CHS elemental microanalysis, X-ray fluorescence (XRF), and FT-IR spectroscopy. Polymers prepared by the three methods have different structures. Both elemental microanalysis and XRF indicated the presence of S in those polymers prepared by treatment with concentrated H2SO4, which were the only ones exhibiting inhibitory and virucidal activity against HIV-1, mediated by their binding to cellular co-receptor binding sites on the virus envelope glycoprotein gp120. Additionally, FT-IR spectroscopy indicated the complete absence of C=O functionality in the H2SO4-prepared PMDA. |
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Authors:
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Marty Ward; Bing Yu; Victor Wyatt; Jelani Griffith; Tara Craft; A Robert Neurath; Nathan Strick; Yun-Yao Li; David L Wertz; John A Pojman; Andrew B Lowe |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-10-20 |
Journal Detail:
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Title: Biomacromolecules Volume: 8 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-12 Completed Date: 2007-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 3308-16 Citation Subset: IM |
Affiliation:
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Department of Polymer Science, 118 College Drive #10076, The University of Southern Mississippi, Hattiesburg, MS 39406-10076, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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chemistry,
pharmacology* HIV Envelope Protein gp120 / metabolism HIV-1 / drug effects*, metabolism Mandelic Acids / chemical synthesis, chemistry*, pharmacology* Molecular Structure Protein Binding Solubility Spectrum Analysis Transition Temperature Water / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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P01 HD 41761/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/HIV Envelope Protein gp120; 0/Mandelic Acids; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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