Document Detail


Anti-HIV-1 activity of poly(mandelic acid) derivatives.
MedLine Citation:
PMID:  17949101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water-soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were prepared via a step-growth mechanism, yielding linear polyesters. The polymers were characterized by CHS elemental microanalysis, X-ray fluorescence (XRF), and FT-IR spectroscopy. Polymers prepared by the three methods have different structures. Both elemental microanalysis and XRF indicated the presence of S in those polymers prepared by treatment with concentrated H2SO4, which were the only ones exhibiting inhibitory and virucidal activity against HIV-1, mediated by their binding to cellular co-receptor binding sites on the virus envelope glycoprotein gp120. Additionally, FT-IR spectroscopy indicated the complete absence of C=O functionality in the H2SO4-prepared PMDA.
Authors:
Marty Ward; Bing Yu; Victor Wyatt; Jelani Griffith; Tara Craft; A Robert Neurath; Nathan Strick; Yun-Yao Li; David L Wertz; John A Pojman; Andrew B Lowe
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-10-20
Journal Detail:
Title:  Biomacromolecules     Volume:  8     ISSN:  1525-7797     ISO Abbreviation:  Biomacromolecules     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-12     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3308-16     Citation Subset:  IM    
Affiliation:
Department of Polymer Science, 118 College Drive #10076, The University of Southern Mississippi, Hattiesburg, MS 39406-10076, USA.
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / chemistry,  pharmacology*
HIV Envelope Protein gp120 / metabolism
HIV-1 / drug effects*,  metabolism
Mandelic Acids / chemical synthesis,  chemistry*,  pharmacology*
Molecular Structure
Protein Binding
Solubility
Spectrum Analysis
Transition Temperature
Water / chemistry
Grant Support
ID/Acronym/Agency:
P01 HD 41761/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/HIV Envelope Protein gp120; 0/Mandelic Acids; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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