Document Detail

The Anti-Fibrotic Peptide Ac-Sdkp: Opportunities For Ace Inhibitor Design.
MedLine Citation:
PMID:  23351021     Owner:  NLM     Status:  Publisher    
The renin-angiotensin system (RAS) is central to regulation of blood pressure and electrolyte homeostasis. Angiotensin-converting enzyme (ACE), a key protease in the RAS, has a range of substrates, including N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP). Ac-SDKP is cleared almost exclusively by ACE and specifically by the N-domain active site of this enzyme. Ac-SDKP is a negative regulator of haematopoietic stem cell differentiation and is a potent anti-fibrotic agent. In this review, the physiological actions of Ac-SDKP will be presented together with the potential clinical utility of raising Ac-SDKP levels. This emphasises the possible opportunity of N-domain selective ACE inhibitors or ACE-resistant Ac-SDKP analogues for the treatment of fibrosis. © 2013 The Authors Clinical and Experimental Pharmacology and Physiology © 2013 Wiley Publishing Asia Pty Ltd.
R G Douglas; M R Ehlers; E D Sturrock
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-27
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors Clinical and Experimental Pharmacology and Physiology © 2013 Wiley Publishing Asia Pty Ltd.
Division of Medical Biochemistry, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
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