Document Detail


Anti-Fibrosis Effect of Scutellarin via Inhibition of Endothelial-Mesenchymal Transition on Isoprenaline-Induced Myocardial Fibrosis in Rats.
MedLine Citation:
PMID:  25268717     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable of decreasing myocardial fibrosis. The aim of the present study is to investigate whether SCU treatment attenuates isoprenaline-induced myocardial fibrosis and the mechanisms of its action. Rats were injected subcutaneously with isoprenaline (Iso) to induce myocardial fibrosis and rats in the SCU treatment groups were intraperitoneally infused with SCU (10 mg·kg-1·d-1 or 20 mg·kg-1·d-1, for 14 days). Post-treatment, cardiac functional measurements and the left and right ventricular weight indices (LVWI and RVWI, respectively) were analysed. Pathological alteration, expression of type I and III collagen, Von Willebrand factor, α-smooth muscle actin, cluster of differentiation-31 (CD31), and the Notch signalling proteins (Notch1, Jagged1 and Hes1) were examined. The administration of SCU resulted in a significant improvement in cardiac function and decrease in the cardiac weight indices; reduced fibrous tissue proliferation; reduced levels of type I and III collagen; increased microvascular density; and decreased expression of α-smooth muscle actin and increased expression of CD31, Notch1, Jagged1 and Hes1 in isoprenaline-induced myocardial fibrosis in rats. Our results suggest that SCU prevents isoprenaline-induced myocardial fibrosis via inhibition of cardiac endothelial-mesenchymal transition potentially, which may be associated with the Notch pathway.
Authors:
Hao Zhou; Xiao Chen; Lingzhi Chen; Xi Zhou; Gaoshu Zheng; Huaiqin Zhang; Weijian Huang; Jiejie Cai
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Publication Detail:
Type:  Journal Article     Date:  2014-09-29
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  19     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  15611-23     Citation Subset:  IM    
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