| Anti-Borrelia burgdorferi antibody response over the course of Lyme neuroborreliosis. | |
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MedLine Citation:
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PMID: 1997408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Characteristic findings on examination of cerebrospinal fluid (CSF) in Lyme neuroborreliosis include mononuclear pleocytosis, oligoclonal immunoglobulin G (IgG) bands, and evidence for local production of specific antibodies. We utilized an immunospot assay to detect cells secreting anti-Borrelia burgdorferi antibodies of different isotypes over the course of disease. Such cells were detected in CSF from 13 consecutive patients with neuroborreliosis examined before treatment. IgG antibody-secreting cells were present in high numbers (mean, 32 cells per 10(4) CSF cells), whereas IgA and IgM antibody-secreting cells were found less frequently and at lower numbers (mean, 5 and 6 cells per 10(4) CSF cells, respectively). Clinical improvement after penicillin treatment was paralleled by a rapid decline of antibody-secreting cells in CSF, but they were still detected, although at lower numbers, in 5 of 10 patients examined more than 6 months after treatment. This specific B-cell response persisted despite clinical improvement. Whether it reflects persistence of antigen is unsettled. |
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Authors:
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S Baig; T Olsson; K Hansen; H Link |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infection and immunity Volume: 59 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-04-02 Completed Date: 1991-04-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1050-6 Citation Subset: IM |
Affiliation:
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Department of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Bacterial / blood, cerebrospinal fluid, immunology* Antibody-Producing Cells / immunology Borrelia burgdorferi Group / immunology* Enzyme-Linked Immunosorbent Assay Female Flagella / immunology Humans Immunoglobulin Isotypes / immunology Lyme Disease / blood, cerebrospinal fluid, immunology* Male Middle Aged Nervous System Diseases / blood, cerebrospinal fluid, immunology*, microbiology Penicillins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Immunoglobulin Isotypes; 0/Penicillins |
| Comments/Corrections | |
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