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Anti-Arthritic Activity of Premna serratifolia Linn., Wood against Adjuvant Induced Arthritis.
MedLine Citation:
PMID:  23407688     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Adjuvant induced arthritis is a chronic crippling, skeleton-muscular disorder having nearest approximation to human rheumatoid arthritis for which there is currently no medicine available effecting a permanent cure. Even modern drugs used for the amelioration of the symptoms, offer only temporary relief and also produce severe side effects. In the indigenous system of medicine, wood of Premna serratifolia Linn., is reported to be useful in the treatment of arthritis. It is a large shrub, distributed throughout Asia, used against a wide variety of diseases. However, no systematic study has been reported regarding its anti-arthritic activity. This work was aimed at the scientific validation of the ethno-pharmacological claim about its anti-arthritic property. In the present study, anti-arthritic activity of ethanol extract of Premna serratifolia Linn., wood is done by Freund's adjuvant induced arthritis model. Loss in body weight during arthritis condition was corrected on treatment with ethanol extract and standard drug, indomethacin. Biochemical parameters such as hemoglobin content, total WBC, RBC, erythrocyte and sedimentation rate were also estimated. The ethanol extract at the dose of 300 mg/kg body weight inhibited the rat paw edema by 68.32% which is comparable with standard drug indomethacin 74.87% inhibition of rat paw edema after 21 days. The results of the current investigation concluded, ethanol extract of Premna serratifolia Linn., wood possess a significant anti-arthritic activity against adjuvant induced arthritis and justifying its therapeutic role in arthritic condition. The observed anti-arthritic activity may be due to the presence of phytoconstituents such as irridiod glycosides, alkaloids, phenolic compounds and flavonoids.
Rekha Rajendran; Ekambaram Krishnakumar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Avicenna journal of medical biotechnology     Volume:  2     ISSN:  2008-2835     ISO Abbreviation:  Avicenna J Med Biotechnol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-02-15     Revised Date:  2013-04-15    
Medline Journal Info:
Nlm Unique ID:  101511065     Medline TA:  Avicenna J Med Biotechnol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  -    
Department of Pharmacognosy and Phytochemistry, Mohamed Sathak A. J. College of Pharmacy, Tamil Nadu, India.
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