| Anti-Ro/SSA antibodies and cardiac arrhythmias in the adult: facts and hypotheses. | |
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MedLine Citation:
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PMID: 20696018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well established that the passive trans-placental passage of anti-Ro/SSA antibodies from mother to foetus is associated with the risk to develop an uncommon syndrome named neonatal lupus (NLE), where the congenital heart block represents the most severe clinical feature. Recent evidence demonstrated that also adult heart, classically considered invulnerable to the anti-Ro/SSA antibodies, may represent a target of the arrhythmogenicity of these autoantibodies. In particular, the prolongation of the QTc interval appears the most frequent abnormality observed in adults with circulating anti-Ro/SSA antibodies, with some data suggesting an association with an increased risk of ventricular arrhythmias, also life threatening. Moreover, even though the association between anti-Ro/SSA antibodies and conduction disturbances is undoubtedly less evident in adults than in infants, from the accurate dissection of the literature data the possibility arises that sometimes also the adult cardiac conduction tissue may be affected by such antibodies. The exact arrhythmogenic mechanisms involved in foetus/newborns and adults, respectively, have not been completely clarified as yet. However, increasing evidence suggests that anti-Ro/SSA antibodies may trigger rhythm disturbances through an inhibiting cross-reaction with several cardiac ionic channels, particularly the calcium channels (L-type and T-type), but also the potassium channel hERG, whose different expression and involvement in the cardiac electrophysiology during lifespan might account for the occurrence of age-related differences. |
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Authors:
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P E Lazzerini; P L Capecchi; F Laghi-Pasini |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 72 ISSN: 1365-3083 ISO Abbreviation: Scand. J. Immunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: England |
Other Details:
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Languages: eng Pagination: 213-22 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine and Immunological Sciences, Division of Clinical Immunology, University of Siena, Italy. lazzerini7@unisi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antinuclear / immunology* Arrhythmias, Cardiac / etiology*, immunology* Humans Ion Channels / immunology Long QT Syndrome / etiology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Ion Channels; 0/SS-A antibodies |
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