| Anti-Angiogenesis Activities of Novel Peptide Complexes: Mitochondria-Disruptive 9mer Peptides Conjugated with the Integrin alpha V beta 3-Homing Cyclic RGD Motif. | |
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MedLine Citation:
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PMID: 23132564 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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RGD peptides are popular drug delivery tools in treating integrin αVβ3-expressing malignant tumors and tumor vasculature cells. We investigated the specific delivery and pharmacological potential of enantiomeric mitochondria-disruptive peptides (RLYLRIGRR-NH(2), RLRLRIGRR-NH(2), ALYLAIRRR-NH(2), and RLLLRIGRR-NH(2)) after conjugation with an integrin αVβ3-homing peptide, cyclic pentameric RGD peptide. The cyclic RGD-conjugated mitochondria-disruptive peptides exhibited specific internalization, apoptosis induction, and cytotoxicity against integrin αVβ3-high-expressing human umbilical vein endothelial cells. Our findings indicate that these novel peptide complexes might prove good anti-angiogenesis reagents. |
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Authors:
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Takashi Iwasaki; Minoru Yamakawa; Ai Asaoka; Tsuyoshi Kawano; Jun Ishibashi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: - ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Faculty of Agriculture, Tottori University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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