| Anti-Albuminuric Effects of the Angiotensin AT1 Receptor Blocker Telmisartan in Hypertensive Patients. | |
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MedLine Citation:
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PMID: 21958392 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We evaluated the anti-hypertensive and anti-albuminuric effect of the angiotensin receptor blocker telmisartan alone and in combination with torasemide and amlodipine. Patients were hypertensive, both diabetics and non-diabetics with persistent microalbuminuria. Our primary endpoint was a change in microalbuminuria levels, while the secondary endpoints were changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine levels, and glomerular filtration rate.After the 16-week treatment period, the patients significantly reduced microalbuminuria levels (76.4 ± 52.4 μg/min; p < 0.001), SBP (16.4 ± 8.7 mmHg; p < 0.001) and DBP (17.7 ± 5.9 mmHg; p < 0.001). Both diabetics and non-diabetics showed an identical pattern of significance with respect to the whole population. Systolic blood pressure, DBP, and microalbuminuria were significantly reduced as a consequence of therapy, both in diabetics and non-diabetics. |
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Authors:
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José C Rodríguez-Pérez; Miguel A García-Bello; Aránzazu Anabitarte-Prieto; Osmel Companioni; Francisco J Nóvoa-Mogollón; Saturnino Suárez-Ortega; Celia Plaza-Toledano; Francisco Rodríguez-Esparragón |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-29 |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: - ISSN: 1525-6006 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Nephrology - Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín , Las Palmas de Gran Canaria , Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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