| Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs. | |
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MedLine Citation:
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PMID: 15556756 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two thia-DCK analogs (3a,b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Compound 3a showed potent anti-HIV activity with an EC50 value of 0.14 microM and a therapeutic index of 1110. However, the corresponding 6-tert-butyl-substituted compound (3b) showed no suppression. The bioassay results indicated that thia-DCK analogs merit attention as potential HIV-1 inhibitors. |
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Authors:
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Ying Chen; Qian Zhang; Beina Zhang; Peng Xia; Yi Xia; Zheng-Yu Yang; Nicole Kilgore; Carl Wild; Susan L Morris-Natschke; Kuo-Hsiung Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 12 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-23 Completed Date: 2005-05-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 6383-7 Citation Subset: IM |
Affiliation:
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Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 200032, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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chemical synthesis*,
pharmacology Cell Line HIV / drug effects Humans Inhibitory Concentration 50 Lactones / chemical synthesis, pharmacology Lymphocytes / virology Structure-Activity Relationship Thiones / chemical synthesis, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AI-33066/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Lactones; 0/Thiones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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