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Anti-β2 glycoprotein I antibodies and pregnancy outcome in antiphospholipid syndrome.
MedLine Citation:
PMID:  23157457     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The relation between pregnancy outcome and single- or double-positivity of anticardiolipin (aCL) and β2 glycoprotein I (aβ2GPI) in antiphospholipid syndrome has yet to be clearly documented. In this article, a total of 191 lupus anticoagulant negative pregnant patients with primary antiphospholipid syndrome were retrospectively divided into three groups: aCL(+)/aβ2GPI(-); aCL(+)/aβ2GPI(+); aCL(-)/aβ2GPI(+). All patients had received medical therapy consisting of prednisone (10-15 mg/d), low-dose aspirin (50 mg/d), and low molecular weight heparin (40 mg/d). The miscarriage rate in the double-positive group was significantly higher than that in the aCL(+)/aβ2GPI(-) group (46.2% vs. 22.1%, p<0.05); the miscarriage rate in the aCL(-)/ aβ2GPI(+) group (36.4%) was not significantly different than the rates of the other two groups (p>0.05). Thus, double-positivity may be a risk factor for pregnancy loss and aβ2GPI antibody may be a better prognostic marker than aCL antibody for pregnancy outcome. © 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Authors:
Xinli Liu; Jing Xiao; Fufan Zhu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-16
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
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