Document Detail

Anthroposophic vs. conventional therapy of acute respiratory and ear infections: a prospective outcomes study.
MedLine Citation:
PMID:  15926617     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Acute respiratory and ear symptoms are frequently treated with antibiotics. Anthroposophic treatment of these symptoms relies primarily on anthroposophic medications.
OBJECTIVE: To compare anthroposophic treatment to conventional treatment of acute respiratory and ear symptoms regarding clinical outcome, medication use and safety, and patient satisfaction.
DESIGN: Prospective, non-randomised comparison of outcomes in patients self-selected to anthroposophic or conventional therapy under real-world conditions.
SETTING: 29 primary care practices in Austria, Germany, Netherlands, UK, and USA. PARTICIPANTS AND THERAPY: 1016 consecutive outpatients aged > or = 1 month, consulting an anthroposophic (n = 715 A-patients) or conventional physician (n = 301 C-patients) with a chief complaint of acute (< or = 7 days) sore throat, ear pain, sinus pain, runny nose or cough. Patients were treated according to the physician's discretion.
PRIMARY OUTCOME: Patients' self-report of treatment outcome (complete recovery/major improvement/slight to moderate improvement/no change/deterioration) at Day 14.
RESULTS: Most common chief complaints were cough (39.9% of A-patients vs. 33.9% of C-patients, p = 0.0772), sore throat (26.3% vs. 23.3%, p=0.3436), and ear pain (20.0% vs. 18.9%, p=0.7302). Baseline chief complaint severity was severe or very severe in 60.5% of A-patients and 53.3% of C-patients (p=0.0444), mean severity (0-4) of complaint-related symptoms was 1.3 +/- 0.7 vs. 1.2 +/- 0.6 (p=0.5197). During the 28-day follow-up antibiotics were prescribed to 5.5% of A-patients and 33.6% of C-patients (p<0.0001), anthroposophic medicines were prescribed to all A-patients and no C-patient.
OUTCOMES: Improvement within 24 hours occurred in 30.9% (221/715) of A-patients and 16.6% (50/301) of C-patients (p<0.0001), improvement within 3 days in 73.1% and 57.1% (p<0.0001). At Day 7 complete recovery or major improvement was reported by 77.1% of A-patients and 66.1% of C-patients (p=0.0004), at Day 14 by 89.7% and 84.4% (p=0.0198). Complete recovery rates at Day 7 were 30.5% and 23.3% (p<0.0001); at Day 14 they were 64.2% and 49.5% (p<0.0001). 69.9% of A-patients and 60.5% of C-patients were very satisfied with their physician (p=0.0043); 95.7% and 83.4% would choose the same therapy again for their chief complaint (p<0.0001). After adjustment for country, gender, age, chief complaint, duration of complaint, previous episode of complaint within last year, and baseline symptom severity, odds ratios favoured the A-group for all these outcomes. Adverse drug reactions were reported in 2.7% of A-patients and 6.0% of C-patients (p=0.0157).
CONCLUSION: Compared to conventional treatment, anthroposophic treatment of primary care patients with acute respiratory and ear symptoms had more favourable outcomes, lower antibiotic prescription rates, less adverse drug reactions, and higher patient satisfaction.
Harald J Hamre; Michael Fischer; Marianne Heger; David Riley; Max Haidvogl; Erik Baars; Eileen Bristol; Michael Evans; Reinhard Schwarz; Helmut Kiene
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  117     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-06-01     Completed Date:  2005-06-24     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  256-68     Citation Subset:  IM    
Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany.
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MeSH Terms
Acute Disease
Anti-Bacterial Agents / adverse effects,  therapeutic use
Child, Preschool
Follow-Up Studies
Middle Aged
Otitis Media / therapy*
Patient Satisfaction
Pharyngitis / therapy
Primary Health Care
Prospective Studies
Respiratory Tract Infections / therapy*
Sinusitis / therapy
Time Factors
Tonsillitis / therapy
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
Wien Klin Wochenschr. 2005 Apr;117(7-8):239-40   [PMID:  15926613 ]
Wien Klin Wochenschr. 2005 Apr;117(7-8):241-2   [PMID:  15926614 ]
Wien Klin Wochenschr. 2005 Jul;117(13-14):500-1   [PMID:  16091879 ]

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