Document Detail

Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in the Iowa Women's Health Study cohort.
MedLine Citation:
PMID:  24114627     Owner:  NLM     Status:  MEDLINE    
Classical myeloproliferative neoplasms (MPNs) are composed of essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF), the etiology of which is largely unknown. We investigated the role of anthropometric, medical and lifestyle factors with risk of MPN in a prospective cohort of 27,370 women aged 55-69 years at enrollment. After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV, 21 MF). Risk factor profiles were mostly unique for the two most common types, ET and PV. ET was associated with energy balance factors including body mass index (RR = 1.52 for >29.3 vs. <23.4 kg/m(2) ; p-trend = 0.042), physical activity (RR = 0.66 for high vs. low; p-trend = 0.04) and adult onset diabetes (RR = 1.82; p = 0.009), while PV was not. PV was associated with current smoking (RR = 2.83; p-trend = 0.016), while ET was not. Regular use of aspirin was associated with lower risk of ET (RR = 0.68; p = 0.017). These results broadly held in multivariate models. Our results suggest distinct etiologies for these MPN subtypes and raise mechanistic hypotheses related to obesity-related inflammatory pathways for ET and smoking-related carcinogenic pathways for PV. Regular aspirin use may lower risk for ET.
Alexis D Leal; Carrie A Thompson; Alice H Wang; Robert A Vierkant; Thomas M Habermann; Julie A Ross; Ruben A Mesa; Beth A Virnig; James R Cerhan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-10-15
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  134     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-01-15     Completed Date:  2014-04-17     Revised Date:  2014-09-26    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1741-50     Citation Subset:  IM    
Copyright Information:
© 2013 UICC.
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MeSH Terms
Aged, 80 and over
Anthropometry / methods
Body Mass Index
Iowa / epidemiology
Life Style
Motor Activity / physiology
Myeloproliferative Disorders / epidemiology*
Obesity / epidemiology
Prospective Studies
Risk Factors
Smoking / epidemiology
Women's Health
Grant Support
P30 CA015083/CA/NCI NIH HHS; R01 CA039742/CA/NCI NIH HHS; R01 CA39742/CA/NCI NIH HHS

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