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Anthropometric, medical history and lifestyle risk factors for myeloproliferative neoplasms in The Iowa Women's Health Study (IWHS) cohort.
MedLine Citation:
PMID:  24114627     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Classical myeloproliferative neoplasms (MPN) are comprised of essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF), the etiology of which is largely unknown. We investigated the role of anthropometric, medical, and lifestyle factors with risk of MPN in a prospective cohort of 27,370 women aged 55-69 years at enrollment. After >250,000 person-years of follow-up, 257 cases of MPN were identified (172 ET, 64 PV, 21 MF). Risk factor profiles were mostly unique for the two most common types, ET and PV. ET was associated with energy balance factors including body mass index (BMI) (RR=1.52 for >29.3 vs. <23.4 kg/m(2) ; p-trend=0.042), physical activity (RR=0.66 for high vs. low; p-trend=0.04), and adult onset diabetes (RR=1.82; p=0.009), while PV was not. PV was associated with current smoking (RR=2.83; p-trend=0.016), while ET was not. Regular use of aspirin was associated with lower risk of ET (RR=0.68; p=0.017). These results broadly held in multivariate models. Our results suggest distinct etiologies for these MPN subtypes and raise mechanistic hypotheses related to obesity-related inflammatory pathways for ET and smoking-related carcinogenic pathways for PV. Regular aspirin use may lower risk for ET. © 2013 Wiley Periodicals, Inc.
Authors:
Alexis D Leal; Carrie A Thompson; Alice H Wang; Robert A Vierkant; Thomas M Habermann; Julie A Ross; Ruben A Mesa; Beth A Virnig; James R Cerhan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-30
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 UICC.
Affiliation:
Department of Internal Medicine, Mayo Clinic, Rochester, MN.
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