| Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine. | |
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MedLine Citation:
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PMID: 17344511 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Few studies in humans have related maternal undernutrition to the size of the adult offspring. OBJECTIVE: The objective was to assess whether reductions in food intake by pregnant women during the Dutch famine of 1944-1945 were related to offspring length, weight, and indexes of adiposity in middle age. DESIGN: We recruited 1) exposed persons born in western Netherlands between January 1945 and March 1946 whose mothers experienced famine during or immediately preceding pregnancy, 2) unexposed persons born in the same 3 institutions during 1943 or 1947 whose mothers did not experience famine during this pregnancy, and 3) unexposed same-sex siblings of persons in series 1 or 2. Anthropometric measurements (n = 427 males and 529 females) were obtained between 2003 and 2005. We defined 4 windows of gestational exposure (by ordinal weeks 1-10, 11-20, 21-30, and 31 through delivery) on the basis of exposure to a ration of <900 kcal/d during the whole 10-wk interval. RESULTS: Exposure to reduced rations was associated with increased weight and greater indexes of fat deposition at several tissue sites in women but not in men (P for interaction <0.01). Measures of length and linear proportion were not associated with exposure to famine. CONCLUSION: Reduced food availability may lead to increased adiposity later in life in female offspring. |
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Authors:
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Aryeh D Stein; Henry S Kahn; Andrew Rundle; Patricia A Zybert; Karin van der Pal-de Bruin; L H Lumey |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 85 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-08 Completed Date: 2007-04-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 869-76 Citation Subset: AIM; IM |
Affiliation:
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Rollins School of Public Health, Emory University, Atlanta, GA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anthropometry Body Composition Body Height Body Mass Index Body Weight Female Humans Interviews as Topic Male Middle Aged Netherlands Patient Selection Pregnancy* Pregnancy Complications / physiopathology* Skinfold Thickness Starvation* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL067914/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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