| Anthropometric indexes, insulin resistance, and serum leptin and lipid levels in women with cryptogenic epilepsy receiving topiramate treatment. | |
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MedLine Citation:
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PMID: 20598547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to investigate the effects of topiramate monotherapy on anthropometric indexes, insulin resistance, and serum leptin and lipid levels in 33 premenopausal women (mean age+/-standard deviation: 26.7+/-7.1years) with cryptogenic epilepsy. Body mass index (BMI), waist circumference and serum leptin, insulin and lipid levels were measured at baseline and at 6months after initiation of topiramate. We found reductions in BMI (p<0.001), waist circumference (p<0.001) and serum high-density lipoprotein (HDL) cholesterol levels (p=0.011). We also found significant improvements in insulin resistance (p=0.023), but not in serum leptin levels (p=0.45). Our results suggest that topiramate treatment in women with epilepsy is associated with reduced BMI and waist circumference and improvement in insulin resistance; however, according to our data, topiramate treatment is also associated with lower HDL cholesterol levels, which may substantially increase vascular disease. |
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Authors:
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Bulent Oguz Genc; Ebru Apaydi Dogan; Umuttan Dogan; Emine Genc |
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Publication Detail:
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Type: Journal Article Date: 2010-07-02 |
Journal Detail:
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Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: 17 ISSN: 1532-2653 ISO Abbreviation: J Clin Neurosci Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: Scotland |
Other Details:
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Languages: eng Pagination: 1256-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neurology, Meram School of Medicine, Selcuk University, Ana Bilim Dali, Meram-Konya 42080, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anthropometry / methods Anticonvulsants / therapeutic use* Body Mass Index Body Weight / drug effects Enzyme-Linked Immunosorbent Assay / methods Epilepsy* / blood, drug therapy, physiopathology Female Fructose / analogs & derivatives*, therapeutic use Humans Insulin Resistance / physiology* Leptin / blood* Lipid Metabolism / drug effects* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Leptin; 30237-26-4/Fructose; 97240-79-4/topiramate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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