| Anthropometric characteristics, cardiac abnormalities and adrenergic activity in patients with primary disorders of sleep. | |
MedLine Citation:
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PMID: 6580372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixty-one patients (pts) with sleep apnea (SA), 35 with narcolepsy (N) and 24 with idiopathic hypersomnolence (H) were studied in the Clinical Research Center. The height to body weight ratio was less than normal in SA pts (0.32 +/- 0.01 vs 0.45 +/- 0.01, p less than 0.01), but normal in N and H pts (0.45 +/- 0.02 and 0.45 +/- 0.01, respectively). Twenty-four hour urinary epinephrine (E) plus norepinephrine (NE) was greater than normal (p less than 0.01), but not different among SA, N and H pts. The incidence of mitral valve prolapse (MVP) was greater in N (49%) and H (58%) compared to SA (20%) (p less than 0.01). The ratio of the pre-ejection period to the left ventricular ejection time (PEP/LVET) was abnormal (greater than 0.42) in 36% of the pts with SA and only in one pt with N and H (p = 0.02). The % shortening of the echocardiographic internal diameter (% delta D) was abnormal (less than 28%) in 28% of pts with SA and normal in all pts with N and H (p = 0.02). The incidence of malignant ventricular dysrhythmias (24 hour Holter) was 26% in SA, 3% in N and 4% in H (p = 0.04). Thus, pts with impaired alertness have high adrenergic tone despite evidence for a role of catecholamines in wakefulness. Left ventricular dysfunction, malignant dysrhythmias and obesity are common findings in SA, while MVP is very common in N and H. |
Authors:
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H Boudoulas; H S Schmidt; R W Clark; P Geleris; S F Schaal; R P Lewis |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of medicine Volume: 14 ISSN: 0025-7850 ISO Abbreviation: J Med Publication Date: 1983 |
Date Detail:
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Created Date: 1984-01-27 Completed Date: 1984-01-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505566 Medline TA: J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 223-38 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anthropometry Arrhythmias, Cardiac / complications Disorders of Excessive Somnolence / physiopathology Epinephrine / urine* Female Heart / physiopathology* Humans Male Middle Aged Mitral Valve Prolapse / complications Narcolepsy / physiopathology Norepinephrine / urine* Obesity / complications Sleep Apnea Syndromes / physiopathology Sleep Disorders / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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RR-34/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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