Document Detail

Anthropometric characteristics, cardiac abnormalities and adrenergic activity in patients with primary disorders of sleep.
MedLine Citation:
PMID:  6580372     Owner:  NLM     Status:  MEDLINE    
Sixty-one patients (pts) with sleep apnea (SA), 35 with narcolepsy (N) and 24 with idiopathic hypersomnolence (H) were studied in the Clinical Research Center. The height to body weight ratio was less than normal in SA pts (0.32 +/- 0.01 vs 0.45 +/- 0.01, p less than 0.01), but normal in N and H pts (0.45 +/- 0.02 and 0.45 +/- 0.01, respectively). Twenty-four hour urinary epinephrine (E) plus norepinephrine (NE) was greater than normal (p less than 0.01), but not different among SA, N and H pts. The incidence of mitral valve prolapse (MVP) was greater in N (49%) and H (58%) compared to SA (20%) (p less than 0.01). The ratio of the pre-ejection period to the left ventricular ejection time (PEP/LVET) was abnormal (greater than 0.42) in 36% of the pts with SA and only in one pt with N and H (p = 0.02). The % shortening of the echocardiographic internal diameter (% delta D) was abnormal (less than 28%) in 28% of pts with SA and normal in all pts with N and H (p = 0.02). The incidence of malignant ventricular dysrhythmias (24 hour Holter) was 26% in SA, 3% in N and 4% in H (p = 0.04). Thus, pts with impaired alertness have high adrenergic tone despite evidence for a role of catecholamines in wakefulness. Left ventricular dysfunction, malignant dysrhythmias and obesity are common findings in SA, while MVP is very common in N and H.
H Boudoulas; H S Schmidt; R W Clark; P Geleris; S F Schaal; R P Lewis
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medicine     Volume:  14     ISSN:  0025-7850     ISO Abbreviation:  J Med     Publication Date:  1983  
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7505566     Medline TA:  J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-38     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / complications
Disorders of Excessive Somnolence / physiopathology
Epinephrine / urine*
Heart / physiopathology*
Middle Aged
Mitral Valve Prolapse / complications
Narcolepsy / physiopathology
Norepinephrine / urine*
Obesity / complications
Sleep Apnea Syndromes / physiopathology
Sleep Disorders / physiopathology*
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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