| Anthrax and the inflammasome. | |
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MedLine Citation:
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PMID: 22207185 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis). This review presents the current understanding of LT-induced activation of Nlrp1 in cells, and its consequences for toxin-mediated effects in rodent toxin and spore challenge models. |
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Authors:
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Mahtab Moayeri; Inka Sastalla; Stephen H Leppla |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-17 |
Journal Detail:
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Title: Microbes and infection / Institut Pasteur Volume: - ISSN: 1769-714X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883508 Medline TA: Microbes Infect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Published by Elsevier Masson SAS. |
Affiliation:
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Laboratory of Bacterial Diseases, Building 33, Room 1W20B, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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