Document Detail

Anthracycline-dependent cardiotoxicity and extracellular matrix remodeling.
MedLine Citation:
PMID:  25288002     Owner:  NLM     Status:  In-Data-Review    
The mechanisms of anthracycline-dependent cardiotoxicity have been studied widely, with the suggested principal mechanism of anthracycline damage being the generation of reactive oxygen species by iron-anthracycline complexes, leading to lipid peroxidation and membrane damage. An increasing number of researchers studying cardiovascular events associated with anthracycline-based chemotherapy are addressing cardiac extracellular matrix (ECM) remodeling. The heart is an efficient muscular pump, with the cardiomyocytes and intramural coronary vasculature of the heart tethered in an ECM consisting of a network of fibrillar, structural proteins, mostly collagens. Increasing evidence suggests that the ECM plays a complex and diverse role in the processes initiated by anthracycline-class drugs that lead to cardiac damage. This review discusses adverse myocardial remodeling induced by anthracyclines and focuses on their mechanisms of action.
Dragana Nikitovic; Ivo Juranek; Martin F Wilks; Maria Tzardi; Aristidis Tsatsakis; George N Tzanakakis
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  146     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1123-30     Citation Subset:  AIM; IM    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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