Document Detail


Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.
MedLine Citation:
PMID:  23545535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC50s) in the nM to μM range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.
Authors:
Jandeli Niemand; Pieter Burger; Bianca K Verlinden; Janette Reader; Annie M Joubert; Annette Kaiser; Abraham I Louw; Kiaran Kirk; Otto Phanstiel; Lyn-Marie Birkholtz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-04-01
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  57     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-15     Completed Date:  2013-10-25     Revised Date:  2013-12-03    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2874-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthracenes / chemistry,  pharmacology*
Antimalarials / chemistry,  metabolism,  pharmacology*
CHO Cells
Cell Line, Tumor
Cricetulus
Erythrocytes / parasitology
Humans
Inhibitory Concentration 50
Malaria, Falciparum / parasitology
Parasitic Sensitivity Tests / methods
Plasmodium falciparum / drug effects*,  growth & development,  metabolism
Polyamines / chemistry,  metabolism,  pharmacology*
Chemical
Reg. No./Substance:
0/Anthracenes; 0/Antimalarials; 0/Polyamines; EH46A1TLD7/anthracene
Comments/Corrections

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