Document Detail

Anthology of the renin-angiotensin system: a one hundred reference approach to angiotensin II antagonists.
MedLine Citation:
PMID:  8315517     Owner:  NLM     Status:  MEDLINE    
AIM: To provide a historical overview of the renin-angiotensin system as a guide to the introduction of a new therapeutic pathway, non-peptide inhibition of a angiotensin II. METHOD: One hundred references were selected as a personal preference, for their originality or for their potential impact on medicine. CONCLUSIONS: This review raises the following questions for future research. (1) Will the long-term cardiovascular effects of angiotensin converting enzyme (ACE) inhibition, angiotensin II antagonism and renin inhibition be similar or not, and dependent or independent of blood pressure levels? (2) What are the local-regional interactions between vasoconstrictor and vasodilator systems, and does the renin-angiotensin system synchronize these regional hemodynamic regulatory mechanisms? (3) If hypertension is the result of an interaction between genetic and environmental factors, do proteins secreted through constitutive pathways contribute to the genetic abnormality (prorenin, angiotensinogen, ACE) while regulated secretion (renin) and other regulatory mechanisms (angiotensin II receptors) provide biological support for the environmental effects?
J Ménard
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  11     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-29     Completed Date:  1993-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S3-11     Citation Subset:  IM    
INSERM U 367, Paris, France.
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MeSH Terms
Angiotensin II / antagonists & inhibitors*
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Gene Expression Regulation / physiology
Hypertension / drug therapy*,  physiopathology
Renin-Angiotensin System / physiology*
Sodium / metabolism
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 11128-99-7/Angiotensin II; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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