Document Detail

Anthocyanins are efficiently absorbed from the small intestine in rats.
MedLine Citation:
PMID:  15333716     Owner:  NLM     Status:  MEDLINE    
Anthocyanins are natural pigments that possess antioxidant activities and are implicated in various health effects. Recent studies showed that the stomach is a site of anthocyanin absorption. However, the fate of anthocyanins in the small intestine remains unknown. We therefore investigated anthocyanin absorption after in situ perfusion of the jejunum + ileum in rats. The intestine was perfused for 45 min with a physiological buffer supplemented with various anthocyanins. Purified anthocyanin glycosides (9.2 nmol/min) or blackberry (9.0 nmol/min) or bilberry (45.2 nmol/min) anthocyanins were perfused. A high proportion of anthocyanin glycosides was absorbed through the small intestine after perfusion. The rate of absorption was influenced by the chemical structure of the anthocyanin and varied from 10.7 (malvidin 3-glucoside) to 22.4% (cyanidin 3-glucoside). Regardless of the anthocyanins perfused, only glycosides were recovered in the intestinal lumen. After perfusion of a high amount of blackberry anthocyanins (600 nmol/min), native cyanidin 3-glucoside was recovered in urine and plasma from the aorta and mesenteric vein. Methylated and/or glucuronidated derivatives were also identified. Analysis of bile samples revealed that cyanidin 3-glucoside and its methylated derivatives (peonidin 3-glucoside + peonidin glucuronide) quickly appeared in bile. This study demonstrated that anthocyanin glycosides are rapidly and efficiently absorbed from the small intestine. Furthermore, anthocyanins are quickly metabolized and excreted into bile and urine as intact glycosides as well as methylated forms and glucuronidated derivatives.
Séverine Talavéra; Catherine Felgines; Odile Texier; Catherine Besson; Claudine Manach; Jean-Louis Lamaison; Christian Rémésy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  134     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2275-9     Citation Subset:  IM    
Laboratoire de Pharmacognosie, Faculté de Pharmacie, 63001 Clermont-Ferrand, France.
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MeSH Terms
Anthocyanins / blood,  chemistry,  metabolism,  pharmacokinetics*,  urine
Bile / metabolism
Chromatography, High Pressure Liquid
Drug Stability
Fruit / chemistry
Glucosides / blood,  metabolism,  urine
Glucuronides / metabolism
Glycosides / pharmacokinetics
Ileum / metabolism
Intestinal Absorption*
Intestine, Small / metabolism*
Jejunum / metabolism
Rats, Wistar
Vaccinium myrtillus / chemistry
Reg. No./Substance:
0/Anthocyanins; 0/Glucosides; 0/Glucuronides; 0/Glycosides; 0/peonidin 3-glucoside; 0/peonidin 3-glucuronide; 7084-24-4/cyanidin 3-O-glucoside

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