| Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action. | |
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MedLine Citation:
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PMID: 22858281 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The broad-spectrum anthelmintic cyclooctadepsipeptide PF1022A is a fungal metabolite from Rosellinia sp. PF1022, which is a Mycelia sterilia found on the leaves of Camellia japonica. A broad range of structurally related cyclooctadepsipeptides has been characterized and tested for anthelmintic activities. These metabolites have been used as starting points to generate semisynthetic derivatives with varying nematocidal capacity. Predominant among these compounds is emodepside, which exhibits a broad nematocidal potential against gastrointestinal and extraintestinal parasites. Here we review the chemical biology and mode of action of cyclooctadepsides with particular attention to PF1022A and emodepside. We illustrate how they target nematode neuromuscular function, opening up new avenues for antiparasitic treatments with potential capability for important selective toxicity. |
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Authors:
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Jürgen Krücken; Achim Harder; Peter Jeschke; Lindy Holden-Dye; Vincent O'Connor; Claudia Welz; Georg von Samson-Himmelstjerna |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-31 |
Journal Detail:
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Title: Trends in parasitology Volume: - ISSN: 1471-5007 ISO Abbreviation: Trends Parasitol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-8-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966034 Medline TA: Trends Parasitol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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