| Anthelmintic activity of Chenopodium album (L) and Caesalpinia crista (L) against trichostrongylid nematodes of sheep. | |
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MedLine Citation:
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PMID: 17826017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM OF THE STUDY: The present study was carried out to determine the anthelmintic activity of Caesalpinia crista (L.) (Fabaceae) seed kernel and Chenopodium album (L.) (Chenopodiaceae) whole plant in order to justify their traditional use in veterinary medicine. MATERIALS AND METHODS: In vitro anthelmintic activity of crude aqueous methanolic extract (AME) of both the plants was determined using mature Haemonchus contortus and their eggs in adult motility assay and egg hatch test, respectively. In vivo anthelmintic activity was evaluated in sheep naturally infected with mixed species of gastrointestinal nematodes by administering crude powder (CP) and AME in increasing doses (1.0-3.0 g/kg). RESULTS: Both plants exhibited dose- and time-dependent anthelmintic effects by causing mortality of worms and inhibition of egg hatching. Caesalpinia crista (LC50=0.134 mg/mL) was found to be more potent than Chenopodium album (LC50=0.449 mg/mL) in egg hatch test. In vivo, maximum reduction in eggs per gram (EPG) of faeces was recorded as 93.9 and 82.2% with Caesalpinia crista and Chenopodium album AME at 3.0 g/kg on day 13 and 5 post-treatment, respectively. Levamisole (7.5 mg/kg), a standard anthelmintic agent, showed 95.1-95.6% reduction in EPG. CONCLUSIONS: These data show that both Caesalpinia crista and Chenopodium album possess anthelmintic activity in vitro and in vivo, thus, justifying their use in the traditional medicine system of Pakistan. |
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Authors:
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Abdul Jabbar; Muhammad Arfan Zaman; Zafar Iqbal; Muhammad Yaseen; Asim Shamim |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-08-02 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 114 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-09-28 Completed Date: 2008-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 86-91 Citation Subset: IM |
Affiliation:
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Chemotherapy Laboratory, Department of Veterinary Parasitology, University of Agriculture, Faisalabad 38040, Pakistan. jabbaruaf@yahoo.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antinematodal Agents / administration & dosage, isolation & purification, therapeutic use* Caesalpinia / chemistry* Chenopodium album / chemistry* Dose-Response Relationship, Drug Feces / parasitology Gastrointestinal Diseases / drug therapy, veterinary Haemonchiasis / drug therapy*, veterinary Haemonchus / drug effects Levamisole / therapeutic use Medicine, Traditional Pakistan Parasite Egg Count Plant Extracts / administration & dosage, isolation & purification, therapeutic use* Seeds Sheep Sheep Diseases / drug therapy Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antinematodal Agents; 0/Plant Extracts; 14769-73-4/Levamisole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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