| Anterior uveitis and hypotony after intravenous cidofovir for the treatment of cytomegalovirus retinitis. | |
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MedLine Citation:
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PMID: 9544639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study aimed to describe the incidence and risk factors for the development of anterior uveitis in patients receiving intravenous cidofovir for the treatment of longstanding cytomegalovirus retinitis. DESIGN: The study design was a retrospective cohort. PARTICIPANTS: Eighteen patients (30 eyes) receiving parenteral cidofovir for the treatment of complicated cytomegalovirus retinitis participated. MAIN OUTCOME MEASURES: The clinical response to parenteral cidofovir; the occurrence of anterior uveitis, and the management and outcome of patients with this complication; and the effect of cidofovir on intraocular pressure measurements were measured. RESULTS: There was no progression or relapse of retinitis in patients receiving intravenous cidofovir. Eight (44%) of the 18 patients developed anterior uveitis, which occurred after a median of 4 doses of intravenous cidofovir. The median CD4+ cell count at the time of development of iritis was 101/mm3. Patients who developed uveitis had a mean increase in serum creatinine over baseline measurements (P = 0.05). The use of human immunodeficiency virus type-1 (HIV-1) protease inhibitors was not different between both groups of patients (P = 1.0). The development of anterior uveitis and visually significant hypotony necessitated withdrawal of cidofovir in only one patient. CONCLUSIONS: Anterior uveitis was a common complication after intravenous cidofovir therapy. Despite the frequency of this complication, continued treatment with intravenous cidofovir was possible in the majority of patients. Patients with anterior uveitis after intravenous cidofovir may be treated successfully with topical corticosteroid therapy and cycloplegic agents. |
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Authors:
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M E Akler; D W Johnson; W J Burman; S C Johnson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ophthalmology Volume: 105 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-04-14 Completed Date: 1998-04-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 651-7 Citation Subset: IM; X |
Affiliation:
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Department of Ophthalmology, University of Colorado Health Sciences Center, Denver 80262, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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drug therapy Adult Antiviral Agents / administration & dosage, adverse effects*, therapeutic use CD4 Lymphocyte Count Cohort Studies Cytomegalovirus Retinitis / drug therapy* Cytosine / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Female Humans Incidence Injections, Intravenous Intraocular Pressure / drug effects Male Middle Aged Ocular Hypotension / chemically induced*, pathology Organophosphorus Compounds / administration & dosage, adverse effects*, therapeutic use Phosphonic Acids* Retrospective Studies Risk Factors Treatment Outcome Uveitis, Anterior / chemically induced*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Organophosphorus Compounds; 0/Phosphonic Acids; 113852-37-2/cidofovir; 71-30-7/Cytosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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