Document Detail


Anterior temporal lobe degeneration produces widespread network-driven dysfunction.
MedLine Citation:
PMID:  24072486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neural organization of semantic memory remains much debated. A 'distributed-only' view contends that semantic knowledge is represented within spatially distant, modality-selective primary and association cortices. Observations in semantic variant primary progressive aphasia have inspired an alternative model featuring the anterior temporal lobe as an amodal hub that supports semantic knowledge by linking distributed modality-selective regions. Direct evidence has been lacking, however, to support intrinsic functional interactions between an anterior temporal lobe hub and upstream sensory regions in humans. Here, we examined the neural networks supporting semantic knowledge by performing a multimodal brain imaging study in healthy subjects and patients with semantic variant primary progressive aphasia. In healthy subjects, the anterior temporal lobe showed intrinsic connectivity to an array of modality-selective primary and association cortices. Patients showed focal anterior temporal lobe degeneration but also reduced physiological integrity throughout distributed modality-selective regions connected with the anterior temporal lobe in healthy controls. Physiological deficits outside the anterior temporal lobe correlated with scores on semantic tasks and with anterior temporal subregion atrophy, following domain-specific and connectivity-based predictions. The findings provide a neurophysiological basis for the theory that semantic processing is orchestrated through interactions between a critical anterior temporal lobe hub and modality-selective processing nodes.
Authors:
Christine C Guo; Maria Luisa Gorno-Tempini; Benno Gesierich; Maya Henry; Andrew Trujillo; Tal Shany-Ur; Jorge Jovicich; Simon D Robinson; Joel H Kramer; Katherine P Rankin; Bruce L Miller; William W Seeley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  136     ISSN:  1460-2156     ISO Abbreviation:  Brain     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-27     Completed Date:  2013-11-25     Revised Date:  2014-03-26    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  2979-91     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aphasia / physiopathology
Brain Mapping*
Dementia / physiopathology*
Female
Humans
Male
Memory / physiology
Middle Aged
Nerve Net / physiopathology*
Neuropsychological Tests
Temporal Lobe / pathology,  physiopathology*
Grant Support
ID/Acronym/Agency:
AG1657303/AG/NIA NIH HHS; AG19724/AG/NIA NIH HHS; NS050915/NS/NINDS NIH HHS; P01 AG019724/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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