Document Detail

Anterior spinal artery syndrome in two children with genetic thrombotic disorders.
MedLine Citation:
PMID:  15832907     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Spinal cord infarction is a well-described, but rare, etiology of myelopathy, especially in children. The most common syndrome, anterior spinal artery syndrome (ASAS), is caused by interruption of blood flow to the anterior spinal artery, producing ischemia in the anterior two-thirds of the cord, with resulting neurologic deficits. Causes of ASAS include aortic disease, thoracolumbar surgery, sepsis, hypotension, and thromboembolic disorders. METHODS: Case reports of 2 patients. RESULTS: Two children developed spinal cord infarctions consistent with ASAS, mostly likely caused by previously undiagnosed thrombotic disorders. A child with prothrombin variant experienced acute bilateral lower limb weakness without any preceding event. Magnetic resonance imaging (MRI) revealed increased T2 signal in the anterior cord from midthoracic level to the conus medullaris. A child with protein S deficiency developed lower limb weakness 1 day after a posterior thoracolumbar fusion for idiopathic scoliosis. Computed tomography (CT) myelogram revealed no spinal cord compression. The prothrombin variant mutation is associated with a 2-fold risk of thrombotic events. Individuals with protein S deficiency have an 8-fold increased risk of thrombosis. CONCLUSION: As knowledge of the coagulation pathways grows, it is likely that more patients with spinal cord infarctions will be diagnosed with genetic thrombotic disorders as the etiology of their injury. We review these two disorders, prothrombin variant and protein S deficiency, and the considerations for long-term anticoagulation.
Kevin N Hakimi; Teresa L Massagli
Related Documents :
1749407 - Cocaine-induced myocardial infarction: clinical observations and pathogenetic considera...
8463767 - Accelerated coronary artery disease after heart transplantation: the role of enhanced p...
6688517 - Mesenteric vein thrombosis and vascular plasminogen activator.
15902827 - Coronary thrombosis related to use of xenadrine rfa.
3307367 - Effects of early high-dose streptokinase intravenously on left ventricular function in ...
12768167 - Thrombolytic therapy during or after cardiopulmonary resuscitation. efficacy and safety...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of spinal cord medicine     Volume:  28     ISSN:  1079-0268     ISO Abbreviation:  J Spinal Cord Med     Publication Date:  2005  
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504452     Medline TA:  J Spinal Cord Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Department of Rehabilitation Medicine, Box 356490, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6490, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anterior Spinal Artery Syndrome / genetics*
Hypoprothrombinemias / complications*
Protein S Deficiency / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Study of the rectal electric activity of the uninhibited rectal detrusor (overactive rectum): a new ...
Next Document:  Concept for a laser guide beacon Shack-Hartmann wave-front sensor with dynamically steered subapertu...