Document Detail

Anterior segment ischaemia with giant cell arteritis.
MedLine Citation:
PMID:  16767208     Owner:  NLM     Status:  MEDLINE    
CASE REPORT: A 69-year-old male presented with bilateral blurred vision, left periocular pain, and headache. Ocular examination revealed a right optic neuropathy and left anterior segment ischaemia. An elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) raised suspicion of giant cell arteritis (GCA), which was confirmed by temporal artery biopsy. Treatment with intravenous methylprednisolone followed by a gradually reducing dose of oral prednisolone improved vision in both eyes.
COMMENTS: GCA typically affects large- and medium-sized vessels. It is a recognised cause of anterior ischaemic optic neuropathy. Anterior segment ischaemia is usually caused by disease of the anterior ciliary arteries not typically affected by GCA. This case illustrates that GCA can rarely cause anterior segment ischaemia, without posterior segment involvement in the same eye.
Elisabeth McKillop; Deepak Tejwani; Cliff Weir; Jeffery Jay
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie     Volume:  41     ISSN:  0008-4182     ISO Abbreviation:  Can. J. Ophthalmol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-07-03     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0045312     Medline TA:  Can J Ophthalmol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  201-3     Citation Subset:  IM    
Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK.
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MeSH Terms
Anterior Eye Segment / blood supply*
Blood Sedimentation
C-Reactive Protein / metabolism
Drug Therapy, Combination
Giant Cell Arteritis / complications*,  diagnosis,  drug therapy
Glucocorticoids / therapeutic use
Ischemia / diagnosis,  drug therapy,  etiology*
Methylprednisolone / therapeutic use
Prednisolone / therapeutic use
Temporal Arteries / pathology
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone; 83-43-2/Methylprednisolone; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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