| Anterior ischemic optic neuropathy secondary to interferon alfa. | |
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MedLine Citation:
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PMID: 7639655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association. DESIGN: Description of the clinical findings in two patients with this condition. SETTING: A neuro-ophthalmology referral center. PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema. INTERVENTIONS: Treatment with aspirin and prednisone in one patient. MAIN OUTCOME MEASURES: Visual acuity, color vision, Goldmann perimetry testing, and fundus photography. RESULTS: Visual loss was mild and generally nonprogressive. The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy. CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa. The underlying pathogenesis is probably multifactorial. |
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Authors:
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V A Purvin |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of ophthalmology Volume: 113 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-12 Completed Date: 1995-09-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1041-4 Citation Subset: AIM; IM |
Affiliation:
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Midwest Eye Institute/Methodist Hospital of Indiana, Indianapolis, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aspirin / therapeutic use Carcinoma, Renal Cell / therapy Fundus Oculi Humans Interferon-alpha / adverse effects*, therapeutic use Ischemia / chemically induced*, drug therapy Kidney Neoplasms / therapy Male Middle Aged Multiple Myeloma / therapy Optic Nerve / blood supply* Optic Nerve Diseases / chemically induced*, drug therapy Prednisone / therapeutic use Vision Disorders / chemically induced Visual Acuity Visual Fields |
| Chemical | |
Reg. No./Substance:
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0/Interferon-alpha; 50-78-2/Aspirin; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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