Document Detail

Anterior ischemic optic neuropathy secondary to interferon alfa.
MedLine Citation:
PMID:  7639655     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association. DESIGN: Description of the clinical findings in two patients with this condition. SETTING: A neuro-ophthalmology referral center. PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema. INTERVENTIONS: Treatment with aspirin and prednisone in one patient. MAIN OUTCOME MEASURES: Visual acuity, color vision, Goldmann perimetry testing, and fundus photography. RESULTS: Visual loss was mild and generally nonprogressive. The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy. CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa. The underlying pathogenesis is probably multifactorial.
V A Purvin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  113     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-12     Completed Date:  1995-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1041-4     Citation Subset:  AIM; IM    
Midwest Eye Institute/Methodist Hospital of Indiana, Indianapolis, USA.
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MeSH Terms
Acute Disease
Aspirin / therapeutic use
Carcinoma, Renal Cell / therapy
Fundus Oculi
Interferon-alpha / adverse effects*,  therapeutic use
Ischemia / chemically induced*,  drug therapy
Kidney Neoplasms / therapy
Middle Aged
Multiple Myeloma / therapy
Optic Nerve / blood supply*
Optic Nerve Diseases / chemically induced*,  drug therapy
Prednisone / therapeutic use
Vision Disorders / chemically induced
Visual Acuity
Visual Fields
Reg. No./Substance:
0/Interferon-alpha; 50-78-2/Aspirin; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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