Document Detail

Anterior corpus callosum atrophy and verbal fluency in multiple sclerosis.
MedLine Citation:
PMID:  1743039     Owner:  NLM     Status:  MEDLINE    
To determine whether different portions of the corpus callosum (CC) are responsible for transferring the information of specific cognitive modalities, eighteen females with relapsing-remitting Multiple Sclerosis (MS) were studied using neuropsychological procedures and Magnetic Resonance Imaging (MRI). Measures of both anterior and posterior CC areas were obtained in patients with MS as well as in eighteen age and sex matched healthy controls. MRI scans were additionally analyzed for each patient in order to evaluate the extent of demyelinating lesions in both periventricular and subcortical areas. Patients with MS exhibited a significant decrease in both the anterior and posterior CC areas compared with normal subjects. The results of statistical analysis showed that, even when the effect of demyelinating lesions was taken into account within a regression equation, the atrophy of anterior CC area strongly affected the performance on verbal fluency task. These data emphasize the importance of the anterior CC area for the interhemispheric transfer of cognitive information associated with verbal fluency.
C Pozzilli; S Bastianello; A Padovani; D Passafiume; E Millefiorini; L Bozzao; C Fieschi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cortex; a journal devoted to the study of the nervous system and behavior     Volume:  27     ISSN:  0010-9452     ISO Abbreviation:  Cortex     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-01-13     Completed Date:  1992-01-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0100725     Medline TA:  Cortex     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  441-5     Citation Subset:  IM    
Department of Neurological Science, University of Rome La Sapienza.
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MeSH Terms
Anomia / diagnosis,  physiopathology,  psychology
Brain Mapping
Corpus Callosum / pathology*
Magnetic Resonance Imaging
Middle Aged
Multiple Sclerosis / diagnosis,  physiopathology*,  psychology
Neuropsychological Tests
Problem Solving / physiology
Psychomotor Performance / physiology
Verbal Behavior / physiology*
Word Association Tests

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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