Document Detail

Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms.
MedLine Citation:
PMID:  20630714     Owner:  NLM     Status:  MEDLINE    
The anterior cingulate cortex (ACC) is located at the rostum of the corpus callosum and involved in both cognitive and emotional brain processes. It has been suggested to be involved in P300 event-related potential generation. A large sample of schizophrenia inpatients and controls was examined in order to assess the potential relationship between ACC volumes and P300 characteristics in patients with more pronounced negative symptoms. In 50 male schizophrenia patients and 50 matched controls, auditory P300 and structural magnetic resonance imaging volume measurements of the ACC were obtained. Patients' negative symptoms were assessed using the PANSS (Positive and Negative Syndrome Scale). Volumetry of ACC subregions revealed a volume reduction in patients with schizophrenia compared with controls in right hemispheric rostral ACC subregions that were most pronounced in more negative schizophrenia patients. There was a positive correlation between PZ P300 amplitude and total ACC volume in the right hemisphere in schizophrenia patients with less negative symptoms. The results support the assumption that structural changes of the ACC are more pronounced in subgroups of schizophrenia patients with more negative psychopathology. In addition, while right hemisphere ACC volumes significantly differ between schizophrenia subgroups, combining measures of event-related potential (ERP) and ACC volumetry does not add additional information.
Ulrich W Preuss; Thomas Zetzsche; Oliver Pogarell; Christoph Mulert; Thomas Frodl; Dirk Müller; Gisela Schmidt; Christine Born; Maximilian Reiser; Hans-Jürgen Möller; Ulrich Hegerl; Eva M Meisenzahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-13
Journal Detail:
Title:  Psychiatry research     Volume:  183     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, Nussbaumstrasse 7, D-80336 Munich, Germany.
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MeSH Terms
Acoustic Stimulation / methods
Analysis of Variance
Brain Mapping
Electroencephalography / methods
Event-Related Potentials, P300 / physiology*
Functional Laterality
Gyrus Cinguli / pathology*
Magnetic Resonance Imaging / methods
Psychiatric Status Rating Scales
Reaction Time / physiology
Schizophrenia / pathology,  physiopathology*
Schizophrenic Psychology*
Statistics as Topic

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