| Anterior cingulate cortical lesion attenuates food foraging in rats. | |
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MedLine Citation:
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PMID: 22683801 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have developed a novel laboratory rodent model to detect competitive, non-competitive and no-hurdle foraging behaviors as seen in natural environment. However, it is not clear which brain region is important for the food foraging activity. In the present study, we evaluated the effect of lesions in the bilateral anterior cingulate cortex (ACC) on the rat food foraging behavior with the established model. In contrast to the sham lesion group (saline microinjection into the ACC), bilateral complete ACC chemical lesions (kainic acid microinjection into the ACC) significantly decreased the amount of foraged food in the competitive food foraging tests, non-competitive or no-hurdle foraging test. Moreover, the deficit of the food foraging activity was more prominent in the competitive food foraging test than in the non-competitive food and no-hurdle foraging test after ACC lesions. No alterations after ACC lesions were found in other behaviors including elevated plus-maze test (EPM), forced swimming test (FST), open field test (OFT), sucrose preference test and exploratory behavior. These findings suggest that the ACC mediate the food foraging-related behaviors. |
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Authors:
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Fang Li; Mingbo Li; Wenyu Cao; Yang Xu; Yanwei Luo; Xiaolin Zhong; Jianyi Zhang; Ruping Dai; Xin-Fu Zhou; Zhiyuan Li; Changqi Li |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-6 |
Journal Detail:
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Title: Brain research bulletin Volume: - ISSN: 1873-2747 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Department of Anatomy and Neurobiology, XiangYa School of Medicine, Central South University, Tongzipo Road 172, Changsha, Hunan, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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