Document Detail


Anterior cingulate cortical lesion attenuates food foraging in rats.
MedLine Citation:
PMID:  22683801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have developed a novel laboratory rodent model to detect competitive, non-competitive and no-hurdle foraging behaviors as seen in natural environment. However, it is not clear which brain region is important for the food foraging activity. In the present study, we evaluated the effect of lesions in the bilateral anterior cingulate cortex (ACC) on the rat food foraging behavior with the established model. In contrast to the sham lesion group (saline microinjection into the ACC), bilateral complete ACC chemical lesions (kainic acid microinjection into the ACC) significantly decreased the amount of foraged food in the competitive food foraging tests, non-competitive or no-hurdle foraging test. Moreover, the deficit of the food foraging activity was more prominent in the competitive food foraging test than in the non-competitive food and no-hurdle foraging test after ACC lesions. No alterations after ACC lesions were found in other behaviors including elevated plus-maze test (EPM), forced swimming test (FST), open field test (OFT), sucrose preference test and exploratory behavior. These findings suggest that the ACC mediate the food foraging-related behaviors.
Authors:
Fang Li; Mingbo Li; Wenyu Cao; Yang Xu; Yanwei Luo; Xiaolin Zhong; Jianyi Zhang; Ruping Dai; Xin-Fu Zhou; Zhiyuan Li; Changqi Li
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-06
Journal Detail:
Title:  Brain research bulletin     Volume:  88     ISSN:  1873-2747     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2012-11-23     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetitive Behavior / physiology*
Competitive Behavior / physiology*
Decision Making
Dietary Sucrose
Exploratory Behavior / physiology
Feeding Behavior / physiology*
Food Preferences / physiology
Gyrus Cinguli / drug effects,  physiology*,  physiopathology,  ultrastructure
Kainic Acid / administration & dosage,  toxicity
Male
Maze Learning / physiology
Microinjections
Neurotoxins / administration & dosage,  toxicity
Physical Endurance / physiology
Rats
Rats, Sprague-Dawley
Reward
Swimming
Chemical
Reg. No./Substance:
0/Dietary Sucrose; 0/Neurotoxins; SIV03811UC/Kainic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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