Document Detail

Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis.
MedLine Citation:
PMID:  20869039     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate cross-sectional areas of conjunctivochalasis and tear meniscus using Fourier-Domain RTVue-100 optical coherence tomography (OCT) before and after conjunctival cauterization and to evaluate inter- and intraobserver reliability.
DESIGN: Prospective, nonrandomized, consecutive case study.
METHODS: A total of 12 eyes of 7 patients with conjunctivochalasis (aged 56 to 87) were evaluated. After topical anesthesia, conjunctival cauterization was performed on the inferior bulbar conjunctiva. All patients underwent anterior segment OCT (AS-OCT) imaging prior to and 4 weeks after the procedure. Cross-sectional tear meniscus and conjunctivochalasis areas at 3 locations (nasal, center, and temporal areas) were measured in all patients.
RESULTS: Nonsignificant increases (P = .177) in cross-sectional tear meniscus area as a whole (3 locations combined) were observed following cauterization. Cross-sectional conjunctivochalasis area measurements significantly decreased in all 3 locations after cauterization (P < .001). Mean cross-sectional conjunctivochalasis area decreased from 0.247 ± 0.24 mm(2) to 0.054 ± 0.79 mm(2). For 2 measurements of cross-sectional tear meniscus area by examiner 1, intraclass correlation coefficients ranged from 0.998 to 0.999. Among 2 examiners, Cronbach's alpha reliability coefficients were as high as 0.993 and 0.997 before and after conjunctival cauterization. Regarding the cross-sectional conjunctivochalasis area measurements, intraclass correlation coefficient values were similar to those of the cross-sectional tear meniscus area, but Cronbach's alpha reliability coefficients were slightly less.
CONCLUSIONS: This study indicates the AS-OCT is a useful and reproducible instrument to measure the cross-sectional area of conjunctiva prolapsing into the tear meniscus of patients with conjunctivochalasis. The method can monitor effectiveness of thermoreduction of conjunctivochalasis.
Koray Gumus; Charlene Hong Crockett; Stephen C Pflugfelder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  150     ISSN:  1879-1891     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-17     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  798-806     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Aged, 80 and over
Conjunctiva / metabolism,  pathology*
Conjunctival Diseases / diagnosis*,  surgery
Cross-Sectional Studies
Diagnostic Techniques, Ophthalmological / instrumentation*
Fourier Analysis
Middle Aged
Observer Variation
Pilot Projects
Prospective Studies
Reproducibility of Results
Tears / metabolism
Tomography, Optical Coherence*
Grant Support
EY11915/EY/NEI NIH HHS; R01 EY011915/EY/NEI NIH HHS; R01 EY011915-13/EY/NEI NIH HHS

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