| Antepartum intravenous immunoglobulin therapy in refractory pemphigoid gestationis: case report and literature review. | |
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MedLine Citation:
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PMID: 20642990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: pemphigoid gestationis is an autoimmune blistering disease affecting pregnant women. Treatment often consists of topical corticosteroids, oral antihistamines, and oral prednisone followed by immunosuppressants. Refractory cases in antepartum patients present a particular therapeutic challenge as the majority of second-line agents are contraindicated until the patient has delivered. OBJECTIVE: the following report describes the case of a 34-year-old woman pregnant for the third time at 16 weeks' gestation. Her previous two pregnancies were complicated by pemphigoid gestationis but were successfully managed with oral prednisone and topical agents. During her third pregnancy, the initial lesions were controlled with oral prednisone, but attempts to decrease her dose resulted in disease flare. CONCLUSION: monthly infusions of intravenous immunoglobulin (40 g intravenously for 3 consecutive days for 120 g total) proved to be successful in reducing the dose of oral prednisone required to maintain disease remission. A healthy baby was delivered at 37.5 weeks. |
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Authors:
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Philip Doiron; Melanie Pratt |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of cutaneous medicine and surgery Volume: 14 ISSN: 1203-4754 ISO Abbreviation: J Cutan Med Surg Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2011-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9614685 Medline TA: J Cutan Med Surg Country: Canada |
Other Details:
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Languages: eng Pagination: 189-92 Citation Subset: IM |
Affiliation:
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Mivhael G. DeGroote School of Medicine, McMaster University, hamilton, ON. philip.doiron@medportal.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Inflammatory Agents / administration & dosage* Female Humans Immunoglobulins, Intravenous / administration & dosage, therapeutic use* Immunologic Factors / administration & dosage, therapeutic use* Pemphigoid Gestationis / drug therapy, therapy* Prednisone / administration & dosage* Pregnancy Pregnancy Trimester, Second Retreatment |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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