Document Detail

Antepartum intravenous immunoglobulin therapy in refractory pemphigoid gestationis: case report and literature review.
MedLine Citation:
PMID:  20642990     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: pemphigoid gestationis is an autoimmune blistering disease affecting pregnant women. Treatment often consists of topical corticosteroids, oral antihistamines, and oral prednisone followed by immunosuppressants. Refractory cases in antepartum patients present a particular therapeutic challenge as the majority of second-line agents are contraindicated until the patient has delivered.
OBJECTIVE: the following report describes the case of a 34-year-old woman pregnant for the third time at 16 weeks' gestation. Her previous two pregnancies were complicated by pemphigoid gestationis but were successfully managed with oral prednisone and topical agents. During her third pregnancy, the initial lesions were controlled with oral prednisone, but attempts to decrease her dose resulted in disease flare.
CONCLUSION: monthly infusions of intravenous immunoglobulin (40 g intravenously for 3 consecutive days for 120 g total) proved to be successful in reducing the dose of oral prednisone required to maintain disease remission. A healthy baby was delivered at 37.5 weeks.
Philip Doiron; Melanie Pratt
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  14     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-20     Completed Date:  2011-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  IM    
Mivhael G. DeGroote School of Medicine, McMaster University, hamilton, ON.
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage*
Immunoglobulins, Intravenous / administration & dosage,  therapeutic use*
Immunologic Factors / administration & dosage,  therapeutic use*
Pemphigoid Gestationis / drug therapy,  therapy*
Prednisone / administration & dosage*
Pregnancy Trimester, Second
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors; 53-03-2/Prednisone

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