Document Detail

Antepartum fetal cerebral hemorrhage not predicted by current surveillance methods in cholestasis of pregnancy.
MedLine Citation:
PMID:  9166326     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The reason for increased fetal mortality in cholestasis of pregnancy is not completely understood. Intracerebral hemorrhage due to coagulation disorders, similar to those reported in the mother, is a possible explanation. CASE: Antepartum fetal death occurred at 37 weeks in a primigravida with cholestasis of pregnancy. The woman was taking no medication. Autopsy revealed extensive cerebral hemorrhage. A cardiotocogram and biophysical profile performed 24 hours and 5 days, respectively, before fetal death had been normal. CONCLUSION: Antepartum fetal death may occur in patients with mild cholestasis who are taking no medication. Intracerebral hemorrhage is a possible cause, and this may be unpredictable with current methods of fetal surveillance. This possibility constitutes an argument in support of delivering these pregnancies as soon as lung maturity is achieved.
A Matos; J Bernardes; D Ayres-de-Campos; B Patrício
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  89     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  803-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Hospital S. João, Porto, Portugal.
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MeSH Terms
Cerebral Hemorrhage / diagnosis*,  etiology
Cholestasis / complications*
Fetal Death / diagnosis,  etiology
Fetal Diseases / diagnosis*,  etiology
Fetal Monitoring*
Predictive Value of Tests
Pregnancy Complications*
Prenatal Care

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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