| Antepartum eclampsia <34 weeks case series: advisable to postpone delivery to administer corticosteroids for fetal pulmonary benefit? | |
| | |
MedLine Citation:
|
PMID: 21072041 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective:To determine if postponement of delivery to administer fetal lung maturation corticosteroids (PDACs) in mothers with antepartum eclampsia <34 weeks gestation benefits the fetus without compromising the mother.Study Design:A case series of 37 maternal-perinatal pairs over a 9-year period with antepartum eclampsia between 24 and 34 weeks gestation from a single tertiary center were reviewed retrospectively. Duration of PDAC, clinical course and maternal-fetal outcomes, including impact of duration of PDAC on neonatal pulmonary function, were recorded for each case. Group assignment was based on length of corticosteroid treatment course before delivery: Group A, 0 to 24 h, n=28; B, 24 to <48 h, n=5; C, 48 h, n=4. Data were collected and analyzed by one-way analysis of variance (ANOVA), ANOVA on ranks, χ(2)-test and Fisher's exact tests where appropriate; statistical significance was determined by a P-value <0.05.Result:Overall, 37 of 68 eclampsia patients in 1999 to 2007 met inclusion criteria. No adverse maternal or fetal event occurred while delivery was postponed. Immediate neonatal intubation or continuous positive airway pressure was required for 23/28 in A, 4/5 in B and 2/4 in C; room air was sufficient at birth for 5/28 in A, 1/5 in B and 2/4 in C. No newborn >33 weeks gestation required INI. Prolonged (that is, >1 day) mechanical ventilation was not required for any infant with a gestational age 32 weeks or PDAC 48 h. Two of three neonatal deaths in group A were attributed to pulmonary insufficiency.Conclusion:PDAC for antepartum preterm eclampsia, especially 32 weeks gestation, appears to offer notable fetal pulmonary benefit without significantly increasing maternal or fetal risk. |
| | |
Authors:
|
K B Tam Tam; S D Keiser; S Sims; J Brewer; M Y Owens; J N Martin |
Publication Detail:
|
Type: Journal Article Date: 2010-11-11 |
Journal Detail:
|
Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 31 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
|
Languages: eng Pagination: 161-5 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Winfred L Wiser Hospital for Women and Infants, University of Mississippi Medical Center, Jackson, MS, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Documenting the NICU design dilemma: comparative patient progress in open-ward and single family roo...
Next Document: Monosomal karyotype in myelodysplastic syndromes, with or without monosomy 7 or 5, is prognostically...